LIMK1 as a Novel Kinase of β‐Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5
Advanced Science, EarlyView.Li et al. innovatively map the kinase‐substrate network in esophageal cancer metastasis. Their study demonstrates that LIM domain kinase 1 (LIMK1) and Cyclin‐dependent kinase 5 (CDK5) synergistically increase the phosphorylation of β‐catenin, thereby activating the Wnt/β‐catenin signaling pathway to promote esophageal cancer metastasis.
Shu‐Jun Li +27 more
wiley +1 more source
Why you can't buy all the Caustic Soda, Soda Ash, Sodium Bicarbonate and Chlorine you want...and what to expect for 1947 and 1948. [PDF]
, 1947 openalex +1 more source
Multi‐Region Brain Organoids Integrating Cerebral, Mid‐Hindbrain, and Endothelial Systems
Advanced Science, EarlyView.Multi‐Region Brain Organoids combine cerebral, mid/hindbrain, and endothelial components into an advanced 3D model capturing 80% of fetal brain cellular diversity. This platform reveals essential endothelial‐neural signaling networks that maintain region‐specific intermediate progenitors during hindbrain development.
Anannya Kshirsagar +10 more
wiley +1 more source
Case report: Reversible Fanconi syndrome due to vitamin D deficiency in a patient with epilepsy harbouring a pathogenic variant in the SLC34A1 gene. [PDF]
Front Endocrinol (Lausanne)Improda N +6 more
europepmc +1 more source
Advanced Science, EarlyView.Different from mitosis, the female meiosis undergoes asymmetric division that produces haploid oocytes and polar body, which is essential for retaining maternal components to support subsequent fertilization and embryo development. However, the underlying mechanisms are still largely unknown.
Yu Li +6 more
wiley +1 more source
Unusual Complications in Cocaine Stuffers: A Case Report. [PDF]
Clin Pract Cases Emerg MedAl-Balushi H +6 more
europepmc +1 more source
THE HYDROGEN ION CONCENTRATION AND BICARBONATE LEVEL OF THE BLOOD IN PNEUMONIA
, 1922 Alvan L. Barach +2 more
openalex +1 more source
DO YOU NEED... AMMONIUM CHLORIDE AMMONIUM BICARBONATE POTASSIUM CARBONATE CAUSTIC POTASH SODIUM NITRITE U.S.P. [PDF]
, 1952 openalex +1 more source
Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis
Advanced Science, EarlyView.Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves +17 more
wiley +1 more source
Post-Dialysis Fatigue Is Not Associated with Serum Lactate Levels in Patients on Chronic Hemodialysis. [PDF]
J Clin MedBossola M +5 more
europepmc +1 more source