Candidate gene resequencing in a large bicuspid aortic valve-associated thoracic aortic aneurysm cohort: SMAD6 as an important contributor [PDF]
Bicuspid aortic valve (BAV) is the most common congenital heart defect. Although many BAV patients remain asymptomatic, at least 20% develop thoracic aortic aneurysm (TAA).
Alaerts, M. (Maaike) +38 more
core +2 more sources
Emergency PCI and TAVR for Acute Myocardial Infarction in Severe Aortic Stenosis Patients
ABSTRACT Transcatheter aortic valve replacement (TAVR) is a viable alternative for patients with symptomatic severe aortic stenosis. Acute myocardial infarction is a contraindication to TAVR. The efficacy of emergency TAVR combined with percutaneous coronary intervention for patients presenting with acute myocardial infarction, severe aortic stenosis ...
Ruiyuan Lin +9 more
wiley +1 more source
Aortic valve dysfunction and aortic dilatation in adults with coarctation of the aorta [PDF]
Objectif: Déterminer la prévalence de la dysfonction de la valve aortique, de la dilatation de l'aorte proximale et des interventions au niveau de la valve aortique et de l'aorte ascendante chez les adultes avec une coarctation de l'aorte.
Clair, M.
core
Transthoracic 3D echocardiographic left heart chamber quantification in patients with bicuspid aortic valve disease [PDF]
Integration of volumetric heart chamber quantification by 3D echocardiography into clinical practice has been hampered by several factors which a new fully automated algorithm (Left Heart Model, (LHM)) may help overcome.
Baggen, V.J.M. (Vivan) +9 more
core +1 more source
Longitudinal 4D Flow MRI‐Derived Wall Shear Stress in Patients With an Abdominal Aortic Aneurysm
ABSTRACT Background 4D flow MRI‐derived parameters such as wall shear stress (WSS) may improve abdominal aortic aneurysm (AAA) progression prediction. Validation of this biomarker is needed, but longitudinal data are lacking. Purpose Investigate longitudinal WSS changes and associations with AAA morphology. Study Type Prospective.
E. Aalbregt +9 more
wiley +1 more source
Use of a targeted, combinatorial next-generation sequencing approach for the study of bicuspid aortic valve [PDF]
BACKGROUND: Bicuspid aortic valve (BAV) is the most common type of congenital heart disease with a population prevalence of 1-2%. While BAV is known to be highly heritable, mutations in single genes (such as GATA5 and NOTCH1) have been reported in few ...
David Newsom +7 more
core +2 more sources
The frequency and severity of congenital heart disease vary extensively in individuals with 22q11.22–23 distal deletions. Reduced gene dosage particularly within the low copy repeat (LCR22) D–E region including MAPK1 and HIC2 conveys risk for these defects.
Tanner J. Nelson +22 more
wiley +1 more source
Background The role of transcatheter aortic valve implantation (TAVI) in bicuspid aortic valve stenosis requires further evaluation, particularly as its use has become comparable to surgical aortic valve replacement. We sought to compare midterm outcomes
Marco Moscarelli +10 more
doaj +1 more source
Abnormal wave reflections and left ventricular hypertrophy late after coarctation of the aorta repair [PDF]
Patients with repaired coarctation of the aorta are thought to have increased afterload due to abnormalities in vessel structure and function. We have developed a novel cardiovascular magnetic resonance protocol that allows assessment of central ...
Khushnood, Abbas +7 more
core +2 more sources
Percutaneous prosthetic venous valves are fabricated by embedding stents in an electrospun matrix that extends luminally to form leaflets. The design shields leaflets from hyperplastic cells, isolates struts from blood contact, and avoids discrete anchoring points.
Dario Arcuti +6 more
wiley +1 more source

