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Diagnosis and Treatment of Bicuspid Aortic Valve Disease
Bicuspid aortic valve disease is the most common congenital cardiac anomaly. The prevalence in the general population is between 0.46% and 1.37%. There is significantly high cardiac morbidity associated with bicuspid aortic valve disease, predomi- nantly due to progressive valve dysfunction (stenosis or regurgitation) that requires surgical ...
Mehmet Akif Cakar, Ercan Aydin
openaire +2 more sources
BackgroundCongenital heart disease is the most common type of birth defect, affecting ≈2% of the population. Malformations involving the cardiac outflow tract and semilunar valves account for >50% of these cases predominantly because of a bicuspid aortic
Sara N. Koenig+5 more
doaj +1 more source
Risk factors for paravalvular leak after transcatheter aortic valve replacement [PDF]
Objective. To assess risk factors for paravalvular leak (PVL) after transcatheter aortic valve implantation (TAVI) in a large single-center cohort, including measurement of aortic valve calcification using a reproducible method. Methods.
Pollari, Francesco
core
Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves. [PDF]
The mesenchymal cushions lining the early embryonic heart undergo complex remodelling to form the membranous ventricular septum as well as the atrioventricular and semilunar valves in later life.
Andrews, WD+3 more
core +1 more source
ABSTRACT Aortic regurgitation (AR) develops in up to 25%−30% of patients with left ventricular assist device (LVAD). Treatment remains challenging since surgery confers significant peri‐operative risk and the lack of valvular calcification renders transfemoral transcatheter aortic valve implantation (TF‐TAVI) with non‐dedicated devices technically ...
Daniel Tai‐Leung Chan+9 more
wiley +1 more source
The living aortic valve: From molecules to function. [PDF]
The aortic valve lies in a unique hemodynamic environment, one characterized by a range of stresses (shear stress, bending forces, loading forces and strain) that vary in intensity and direction throughout the cardiac cycle.
Bertazzo, S+5 more
core +1 more source
Interventional therapies for chronic heart failure: An overview of recent developments
Abstract Heart failure (HF), the final manifestation of most cardiovascular diseases, has become a major global health concern, affecting millions of individuals. Despite basic drug treatments, patients present with high morbidity and mortality rates. However, recent advancements in interventional therapy have shown promising results in improving the ...
Bingchen Guo+7 more
wiley +1 more source
Expert consensus recommendations on the cardiogenetic care for patients with thoracic aortic disease and their first-degree [PDF]
Background: Thoracic aortic aneurysm (TAA) is a potentially life-threatening disorder with a strong genetic component. The number of genes implicated in TAA has increased exponentially over the last decade.
Bekkers, S.C.A.M.+14 more
core +1 more source
Increased calcification by erythrophagocytosis in aortic valvular interstitial cells
Abstract Background Calcific aortic valve disease (CAVD) progresses over time to severe aortic stenosis and eventually heart failure. Recent evidence indicates that intraleaflet haemorrhage (ILH) strongly promotes CAVD progression. However, it remains poorly understood how it mechanistically contributes to valvular calcification.
Zihan Qin+3 more
wiley +1 more source
A very rare case of late diagnosis of cor triatriatum sinistrum [PDF]
L
Czerny, Martin+3 more
core +1 more source