Results 131 to 140 of about 29,296 (236)

NFS1 Regulates IDH2 to Attenuate Abdominal Aortic Aneurysms via Interacting With SP2

Advanced Science, Volume 13, Issue 14, 9 March 2026.
The loss of NFS1 leads to its reduced binding with the transcription factor SP2, resulting in decreased expression of the downstream gene Idh2. This causes a shift in energy supply toward glycolysis in VSMCs, ultimately contributing to the occurrence and progression of AAA.
Luzheng Zhang, Yu Zhang, Dezhong Wen, Suxiang Guo, Xiaohui Qi, Heng Wang, Yujin Sun, Guangdong Yang, Yuehong Wang, Song Xue   +9 more
wiley   +1 more source

Non‐RASopathy Genetic Syndromes Identified as the Molecular Cause of Disease in Patients Previously Diagnosed With Noonan Syndrome

American Journal of Medical Genetics Part A, Volume 200, Issue 3, Page 661-672, March 2026.
ABSTRACT Noonan Syndrome (NS) is a clinically and genetically heterogeneous condition characterized by typical facial dysmorphisms, short stature, congenital heart defects, and developmental delays. While variants in genes such as PTPN11, SOS1, and RAF1 account for most genetically confirmed cases, diagnosis is challenging due to phenotypic overlap ...
Gabriela Jeesoo Kim, Alexsandra Christianne Malaquias, Debora Romeo Bertola, Raissa Carneiro Rezende, Laurana De Polli Cellin, Lucas Vieira Lacerda Pires, Ana Maria Santillan‐Vasconez, Antônio Marcondes Lerario, Renata da Cunha Scalco, Alexander Augusto de Lima Jorge   +9 more
wiley   +1 more source

Long-term durability of bioprosthetic aortic valve replacement in young patients with bicuspid aortic stenosisCentral MessagePerspective

JTCVS Structural and Endovascular
Objective: To examine long-term surgical aortic valve replacement (SAVR) outcomes for young (ie, younger than age 65 years) patients with bicuspid aortic valve and aortic stenosis (AS) with or without concomitant aneurysm.
Christopher K. Mehta, MD, Tom X. Liu, MD, MS, Abigail S. Baldridge, DrPh, Jane Kruse, BSN, Jyothy Puthumana, MD, Robert O. Bonow, MD, Duc T. Pham, MD, Douglas R. Johnston, MD, S. Christopher Malaisrie, MD, Patrick M. McCarthy, MD   +9 more
doaj   +1 more source

Burden of Liver Disease Among Individuals With Turner Syndrome and Klinefelter Syndrome: A Comprehensive Perspective

Chronic Diseases and Translational Medicine, Volume 12, Issue 1, Page 39-48, March 2026.
ABSTRACT The liver is increasingly recognized as a major regulator of systemic cardio‐renal‐metabolic health. Evidence is mounting that sex‐chromosome dosage per se itself, independent of gonadal sex hormones, modulates hepatic physiology and liver disease risk.
Mohamad Jamalinia, Amedeo Lonardo, Ralf Weiskirchen   +2 more
wiley   +1 more source

Point on the Aortic Bicuspid Valve. [PDF]

Life (Basel), 2022
Bernard C, Morgant MC, Guillier D, Cheynel N, Bouchot O.   +4 more
europepmc   +1 more source

Endogenous reference genes for gene expression studies on bicuspid aortic valve associated aortopathy in humans

, 2016
Bicuspid aortic valve (BAV) disease is the most common congenital cardiac abnormality and predisposes patients to life-threatening aortic complications including aortic aneurysm.
Cagampang, Felino, Harrison, Oliver, Moorjani, Narain, Ohri, Sunil, Torrens, Christopher   +4 more
core   +3 more sources

Evaluation of the Haemodynamic Behaviour of Stenosed Aortic Heart Valves Using Fluid Structure Interaction Modelling

International Journal for Numerical Methods in Biomedical Engineering, Volume 42, Issue 3, March 2026.
The haemodynamic environment of generic calcific and rheumatic aortic valves of various severities is analysed through the use of 3D FSI modelling techniques. For the same severity and similar flow rates, the rheumatic valves offer higher resistance to the flow of blood compared to the calcific valves.
Lindi Grobler Kock, Ryno Laubscher, Johan van der Merwe, Martin P. Venter, Anton F. Doubell, Philip G. Herbst   +5 more
wiley   +1 more source

A Meta-Analysis of Short-Term Outcomes of TAVR versus SAVR in Bicuspid Aortic Valve Stenosis and TAVR Results in Different Bicuspid Valve Anatomies. [PDF]

J Clin Med, 2023
Improta R, Di Pietro G, Kola N, Birtolo LI, Colantonio R, Bruno E, Tocci M, Giansante A, Sannino M, Zullino V, Monosilio S, Cimino S, Maestrini V, Severino P, Badagliacca R, Lavalle C, Celli P, Saade W, Musto C, D'Ascenzo F, Miraldi F, Vizza CD, Sardella G, Mancone M.   +23 more
europepmc   +1 more source

Incidence of bicuspid valve related aortic dissection: a systematic review and meta-analysis. [PDF]

Ann Cardiothorac Surg, 2022
Wilson-Smith AR, Eranki A, Muston B, Kamalanathan H, Yung A, Williams ML, Sahai P, Zi C, Michelena H.   +8 more
europepmc   +1 more source

Bicuspid Aortic Valve Disease: Classifications, Treatments, and Emerging Transcatheter Paradigms

Structural Heart
Bicuspid aortic valve (BAV) is a common congenital valvular malformation, which may lead to early aortic valve disease and bicuspid-associated aortopathy. A novel BAV classification system was recently proposed to coincide with transcatheter aortic valve
Ankur Kalra, MD, Rajiv Das, MB ChB, MD, Mohammad Alkhalil, MD, DPhil, Iryna Dykun, MD, Alessandro Candreva, MD, Omar Jarral, MBBS, PhD, Syed M. Rehman, MBBS, Monil Majmundar, MD, Kunal N. Patel, MD, MPH, Josep Rodes-Cabau, MD, PhD, Michael J. Reardon, MD, Rishi Puri, MBBS, PhD   +11 more
doaj   +1 more source