Results 241 to 250 of about 401,050 (285)

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

open access: yesChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel   +5 more
wiley   +1 more source

Development of Sustainable Rubber Composites Reinforced with Silk Fabric for High-Performance Bicycle Tires: Material Characterization and Prototype Testing. [PDF]

open access: yesACS Omega
Choosang N   +9 more
europepmc   +1 more source

2,3‐Dichloro‐5,6‐Dicyano‐1,4‐Benzoquinone (DDQ)‐Mediated CC Bond Formation: Redox Strategies from Stoichiometric to Catalytic Systems

open access: yesChemistryOpen, EarlyView.
2,3‐Dichloro‐5,6‐dicyano‐1,4‐benzoquinone serves as a versatile oxidant and redox catalyst for CC bond formation through hydride abstraction or single‐electron transfer. Stoichiometric and catalytic systems enable benzylic, allylic, and aromatic CH activation under mild, metal‐free conditions, providing sustainable routes to complex and bioactive ...
Dohoon Cha, Sun‐Joon Min
wiley   +1 more source

Toronto's Supervised Consumption Sites and Local Crime.

open access: yesJAMA Netw Open
Panagiotoglou D   +6 more
europepmc   +1 more source

Unveiling human–wildlife interactions in the context of livestock grazing abandonment and the return of large carnivores, ungulates and vultures: A stakeholder perspective

open access: yesPeople and Nature, EarlyView.
Abstract Pastoral practices remain a widespread economic activity across European mountain regions. However, the viability of this activity may be threatened by the recovery of large wild vertebrates associated with passive rewilding, leading to the so‐called human–wildlife conflicts.
P. Acebes   +4 more
wiley   +1 more source

What does coexistence mean? Insight from place‐based trajectories of pastoralists and bears encounters in the Pyrenees

open access: yesPeople and Nature, EarlyView.
Abstract The recovery of large carnivores in Europe raises issues related to sharing landscape with humans. Beyond technical solutions, it is widely recognized that social factors also contribute to shaping coexistence. In this context, scholars increasingly stress the need to adopt place‐based approaches by analysing how humans and wildlife interact ...
Alice Ouvrier   +7 more
wiley   +1 more source

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