Results 91 to 100 of about 41,404 (206)

Synthetic Entries to Substituted Bicyclic Pyridones

, 2016
The synthesis of 6,6- and 5,6-bicyclic pyridone scaffolds has been completed using (i) an intramolecular Mitsunobu reaction and/or (ii) hydrolysis of a bicyclic pyridinium salt intermediate.
Timothy Gallagher (1261572), Muna Abdi (2464654), Dachen Cheng (2368105), Laura Croft (2464657), Andrew Lightfoot (2464651)   +4 more
core   +1 more source

Secondary 3‐Chloropiperidines: Powerful Alkylating Agents

ChemistryOpen
In previous works, we demonstrated that tertiary 3‐chloropiperidines are potent chemotherapeutics, alkylating the DNA through the formation of bicyclic aziridinium ions. Herein, we report the synthesis of novel secondary 3‐chloropiperidine analogues. The
Mats Georg, Dr. Lina Alexandra Laping, Veronica Billo, Prof. Dr. Barbara Gatto, Prof. Dr. Peter Friedhoff, Prof. Dr. Richard Göttlich   +5 more
doaj   +1 more source

Bicyclic peptide inhibitor of urokinase-type plasminogen activator:mode of action

, 2013
The development of protease inhibitors for pharmacological intervention has taken a new turn with the use of peptide-based inhibitors. Here, we report the rational design of bicyclic peptide inhibitors of the serine protease urokinase-type plasminogen ...
Jensen, Knud Jørgen, Christensen, Anni, Jensen, Berit Paaske, Jiang, Longguang, Nielsen, Niels Chr., Roodbeen, Renée, Huang, Mingdong, Nielsen, Jakob T., Mulder, Frans, Andreasen, Peter, Jensen, Jan Kristian   +10 more
core   +1 more source

A Tandem Photocycloaddition—Ring Expansion Strategy for the Synthesis of Fused [5.3.0] Triketone

Molbank
A tandem synthetic sequence involving photo-induced intramolecular [2+2] cycloaddition followed by acid-promoted ring expansion was developed to access the novel bicyclic triketone framework.
Xin-Yi Hsiao, Chern Chuang, Gary Jing Chuang   +2 more
doaj   +1 more source

On bicyclic reflexive graphs

, 2008
A simple graph is said to be reflexive if the second largest eigenvalue of a (0,1)-adjacency matrix does not exceed 2. We use graph modifications involving Smith trees to construct four classes of maximal bicyclic reflexive ...
Mihailović, Bojana, Rašajski, Marija, Radosavljević, Zoran   +2 more
core   +1 more source

Conversion of Bicycle into Electric Bicycle

International Journal of Innovations in Engineering and Science, 2022
Kartik Reddiwar, Aakash Khadikar, Kustubh Tichkule, Sachin Bokde, Divyanshu Thakre, Pooja Tirpude, Sonal Badode, Sonali Dhande   +7 more
openaire   +1 more source

Bicyclic peptides: types, synthesis and applications

, 2019
Bicyclic peptides form one of the most promising platforms for drug development owing to their biocompatibility, similarity and chemical diversity to proteins, and they are considered as a possible practical tool in various therapeutic and diagnostic ...
Ahangarzadeh, Shahrzad, Ranjbari, Javad, Tayebi, Lobat, Mokhtarzadeh, A., Barati, Mahmood, Hosseinzadeh, Simzar, Hosseinzadeh, S., Kanafi, M.M., Barati, M., Ahangarzadeh, S., Tayebi, L., Kanafi, Mohammad M., Ranjbari, J., Mokhtarzadeh, Ahad   +13 more
core  

Hosoya Indices of Bicyclic Graphs

, 2009
Given a molecular graph G, the Hosoya index Z(G) of G is defined as the total number of the matchings of the graph. Let Bn denote the set of bicyclic graphs on n vertices.
Xuechao Li, Zhongxun Zhu, Zhu, Zhongxun, Li, Shuchao, Shuchao Li, Li, Xuechao   +5 more
core  

Phage selection of bicyclic peptides

Bicyclic peptides are small, constrained peptides that can bind with high affinity and selectivity to protein targets. Their small size provides a number of advantages over larger protein-based ligands, including access to chemical synthesis, better ...
Rebollo, Inmaculada Rentero, Heinis, Christian   +1 more
core   +1 more source

Delay at bicycle passages and bicycle crossings

, 2022
In September 2014, a new regulation was proposed in Sweden, which indicates aset of rules of giving way under different types of bicycle intersections. Meanwhile,new definitions were endued to bicycle passages and bicycle crossings. After thepriority of cyclists is guaranteed at bicycle crossings, potential delay for motorvehicles in the mainstream ...
openaire   +1 more source