Results 31 to 40 of about 41,404 (206)

Unlocking Therapeutic Potential of Novel Thieno-Oxazepine Hybrids as Multi-Target Inhibitors of AChE/BChE and Evaluation Against Alzheimer’s Disease: In Vivo, In Vitro, Histopathological, and Docking Studies

Pharmaceuticals
Background: Alzheimer’s disease (AD) is largely linked with oxidative stress, the accumulation of amyloid-β plaques, and hyperphosphorylated τ-protein aggregation.
Khulood H. Oudah, Mazin A. A. Najm, Triveena M. Ramsis, Maha A. Ebrahim, Nirvana A. Gohar, Karema Abu-Elfotuh, Ehsan Khedre Mohamed, Ahmed M. E. Hamdan, Amira M. Hamdan, Reema Almotairi, Shaimaa R. Abdelmohsen, Khaled Ragab Abdelhakim, Abdou Mohammed Ahmed Elsharkawy, Eman A. Fayed   +13 more
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The first Dirichlet eigenvalue of bicyclic graphs [PDF]

, 2012
summary:In this paper, we have investigated some properties of the first Dirichlet eigenvalue of a bicyclic graph with boundary condition. These results can be used to characterize the extremal bicyclic graphs with the smallest first Dirichlet eigenvalue
Zhang, Xiao-Dong, Zhang, Guang-Jun
core   +1 more source

Computer-aided design, synthesis, and biological evaluation of [4.3.0] bicyclic prolyl oligopeptidase and fibroblast activation protein-α dual inhibitors

, 2021
We have previously described several different chemical series of bicyclic prolyl oligopeptidase (POP) inhibitors as probes for neurodegenerative diseases that demonstrated nanomolar activity in vitro and submicromolar activity in cellulo.
Nicolas, Moitessier, Maud, Pousse, Anthony, Mittermaier, Damien, Hedou, Jessica, Plescia, Caroline, Dufresne, Anne, Labarre   +6 more
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Chemistry Teacher Trainees’ use of Molecular Models in Learning Spiro and Bicyclic Compounds

Science Education International, 2022
The study diagnosed chemistry teacher trainees’ difficulties in naming and writing structures of spiro and bicyclic compounds. The case study design was conducted in a constructivist environment to enhance chemistry teacher trainees’ ability to construct,
Claudia Quayson , Kwarteng Twumasi Ankrah , Ernest Koranteng , Ruby Hanson   +3 more
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Ring-opening metathesis of some strained bicyclic systems; stereocontrolled access to diolefinated saturated heterocycles with multiple stereogenic centers

Beilstein Journal of Organic Chemistry, 2018
Ring-opening metathesis (ROM) of various unsaturated, constrained bicyclic ring systems has been investigated with the use of commercial ruthenium-based catalysts. Starting from various cyclodienes, the corresponding derived bicyclic lactone, lactam, and
Zsanett Benke, Melinda Nonn, Márton Kardos, Santos Fustero, Loránd Kiss   +4 more
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A practical preparation of bicyclic boronates via metal-free heteroatom-directed alkenyl sp 2-C‒H borylation

Communications Chemistry, 2023
Bicyclic boronates play critical roles in the discovery of functional materials and antibacterial agents, especially against deadly bacterial pathogens. Their practical and convenient preparation is in high demand but with great challenge.
Pei-Ying Peng, Gui-Shan Zhang, Mei-Ling Gong, Jian-Wei Zhang, Xi-Liang Liu, Dingding Gao, Guo-Qiang Lin, Qing-Hua Li, Ping Tian   +8 more
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BICYCLE ACCIDENTS. [PDF]

The Lancet, 1892
n ...
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Generalized bicycles

Discrete Applied Mathematics, 1997
Let \(G=(V,E)\) be a graph with \(n\) vertices, and let \(M\) be a (left) modul over a principal ideal domain \(D\). Let \(W_0(M)\) and \(W_1(M)\) denote the modules of all vertex and edge weightings over \(M\), respectively. An incidence weighting \(\eta\) of \(G\) is a weighting of each incident vertex-edge pair \((v, e)\) with an element of \(D ...
Kenneth A. Berman, Yanpei Liu
openaire   +1 more source

Bridged Bicyclic Building Block Upgrading: Photochemical Synthesis of bicyclo[3.1.1]heptan-1-Amines

, 2020
Compounds containing bridged bicyclic carbon skeletons are desirable building blocks for medicinal chemistry. However, as a result of their inefficient, linear syntheses, commercially available compounds of this sort are plagued by high costs and/or a ...
Alexander, Harmata, Madison, Sowden, Corey, Stephenson   +2 more
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On the inverse mostar index problem for molecular graphs [PDF]

Transactions on Combinatorics
Mostar indices are recently proposed distance-based graph invariants, that already have been much investigated and found applications. In this paper, we investigate the inverse problem for Mostar indices of unicyclic and bicyclic molecular graphs.
Liju Alex, Ivan Gutman
doaj   +1 more source