Results 11 to 20 of about 41,404 (206)

Bicyclic molecular graphs with the greatest energy [PDF]

Journal of the Serbian Chemical Society, 2008
The molecular graph Qn is obtained by attaching hexagons to the end vertices of the path graph Pn-12. Earlier empirical studies indicated that Qn has greatest energy among all bicyclic n-vertex (molecular) graphs.
IVAN GUTMAN, SLAVKO RADENKOVIC, BORIS FURTULA   +2 more
doaj   +5 more sources

The Maximal Total Irregularity of Bicyclic Graphs [PDF]

Journal of Applied Mathematics, 2014
In 2012, Abdo and Dimitrov defined the total irregularity of a graph G=(V,E) as irrtG=1/2∑u,v∈VdGu-dGv, where dGu denotes the vertex degree of a vertex u∈V.
Lihua You, Jieshan Yang, Yingxue Zhu, Zhifu You   +3 more
doaj   +2 more sources

Biocompatible and selective generation of bicyclic peptides

, 2022
Bicyclic peptides possess superior properties for drug discovery; however, their chemical synthesis is not straightforward and often neither biocompatible nor fully orthogonal to all canonical amino acids.
Alexandra, Coram, Sven, Ullrich, Josemon, George, Christoph, Nitsche, Richard, Morewood   +4 more
core   +1 more source

Properties of the subsemigroups of the bicyclic monoid [PDF]

, 2002
In this paper we study some properties of the subsemigroups of the bicyclic monoid B, by using a recent description of its subsemigroups. We start by giving necessary and sufficient conditions for a subsemigroup to be finitely generated.
Ruskuc, Nik, Ruškuc, N., Descalco, L., L. Descalço , et al.   +3 more
core   +1 more source

Ring-Opening Fluorination of Bicyclic Azaarenes

, 2021
We have discovered a ring-opening fluorination of bicyclic azaarenes. Upon treatment of bicyclic azaarenes such as pyrazolopyridines with electrophilic fluorinating agents, fluorination of the aromatic ring is followed by a ring-opening reaction ...
Kenta, Kato, Masayuki, Komatsuda, Junichiro, Yamaguchi, Bunnai, Saito, Hiroyuki, Takada, Ayane, Suto, Hiroki, Kondo Jr.   +6 more
core   +1 more source

Convenient synthesis of an enantiomerically pure bicyclic proline and its N-oxyl derivatives [PDF]

, 2008
An enantiomerically pure bicyclic proline derivative was prepared by cis-selective allylation and diastereospecific intramolecular alkylation starting from d-pipecolinic acid.
Demizu, Yosuke, Onomura, Osamu, Mori, Hiroyuki, Shiigi, Hirofumi, Matsumoto, Kazuya   +4 more
core   +1 more source

An Efficient Synthesis of the Bicyclic Darunavir Side Chain Using Chemoenzymatic Catalysis

, 2022
Herein, we describe a chemoenzymatic synthesis of the bicyclic fragment of Darunavir. A ketoreductase was identified using metagenomic mining to catalyze a highly enantio- and diastereoselective dynamic kinetic resolution of a -ketolactone.
Jesmine, Lim, James, Finnigan, Paul, Riehl, Todd , Hyster, Simon, Charnock   +4 more
core   +1 more source

Fused bicyclic piperidines and dihydropyridines by dearomatising cyclisation of the enolates of nicotinyl-substituted esters and ketones

Beilstein Journal of Organic Chemistry, 2010
The silyl enol ether derivatives of ketones or esters tethered by a hydrocarbon or ether linkage to the 3-position of a pyridine ring undergo dearomatising nucleophilic attack on the ring once it is activated (as an acylpyridinium species) by the ...
Heloise Brice, Jonathan Clayden, Stuart D. Hamilton   +2 more
doaj   +1 more source

Genetically-Encoded Discovery of Proteolytically Stable Bicyclic Inhibitors of Morphogen NODAL

, 2021
In this manuscript, we developed a Two-fold Symmetric Linchpin (TSL) that converts readily available phage display peptides libraries made of 20 common amino acids to genetically-encoded libraries of bicyclic peptides displayed on phage.
Dmitriy, Volochnyuk, Yu-Shan, Lin, Serhii, Kharchenko, Vivian, Triana, Mark, Miskolzie, Olena, Bilyk, Ratmir, Derda, Raja, Mukherjee, Antoine, Henninot, Jeffrey Y. K., Wong, John J., Postovit, John, Dwyer, Jiayuan, Miao, Anna, Iampolska   +13 more
core   +1 more source

Bicyclic peptide-enhanced covalent inhibitor of SARS-CoV-2 3CL protease [PDF]

Exploration of Drug Science
Aim: Develop technology to apply bicyclic peptides for discovering covalent inhibitors of proteases and use this technology to create bicyclic peptide—warhead conjugates for targeting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3C ...
Qian Wang, Yanhui Wang, Jian Li, Hong Liu, Shiyu Chen   +4 more
doaj   +1 more source