Results 1 to 10 of about 24,750 (163)

Identification of an αvβ3-targeting bicyclic peptide with atypical norArg-Gly-Asp sequence [PDF]

Communications Chemistry
Bicyclic peptides, which integrate the advantageous properties of small molecules and antibodies, have emerged as a promising class of therapeutic candidates.
Haijian Yang, Hui Pan, Ting Ran, Wenyan Dong, Wencong Pan, Jianhui Tan, Jingjing Sun, Roderich D. Süssmuth, Wu Su, Guiyang Yao   +9 more
doaj   +2 more sources

Flavouring Group Evaluation 87, Revision 3 (FGE.87Rev3): Consideration of bicyclic secondary alcohols, ketones and related esters evaluated by JECFA (63rd meeting) structurally related to bicyclic secondary alcohols, ketones and related esters evaluated in FGE.47Rev1 [PDF]

EFSA Journal
The Panel on Food Additives and Flavourings (FAF) of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA) and to decide ...
EFSA Panel on Food Additives and Flavourings (FAF), Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Bastos, Polly Boon, Biagio Fallico, Rex FitzGerald, María José Frutos Fernández, Bettina Grasl‐Kraupp, Ursula Gundert‐Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, Romualdo Benigni, Gisela Degen, Karl‐Heinz Engel, Maria Carfí, Carla Martino   +21 more
doaj   +2 more sources

Bismuth Bicycles. [PDF]

J Pept Sci
ABSTRACT Bicyclic peptides are emerging as next generation therapeutics by combining the affinity and specificity of antibodies with the synthetic convenience of small molecules. Phage‐encoded libraries of bicyclic peptides enable the discovery of high‐affinity molecules against virtually any protein target.
Voss S, Sagar A, Tiberghien A, Hughes RJL, Chen L, Rioja I, Frigerio M, Skynner MJ, Spring DR.   +8 more
europepmc   +3 more sources

Conformation-driven reversibility control in ring-opening metathesis polymerization of non-bicyclic cyclooctenes [PDF]

Nature Communications
Reversible ring-opening metathesis polymerization (ROMP) of cyclooctene (COE) derivatives remains a challenge due to their high ring strain energies (RSEs).
Trimbak Baliram Mete, Kyungmin Choi, Honghui Zhang, Seulchan Lee, Ji Hoon Park, Youn K. Kang, Hajime Hirao, Soon Hyeok Hong   +7 more
doaj   +2 more sources

CONSTRUCTION OF BICYCLIC GRAPH AND ITS APPLICATION IN TRANS JOGJA ROUTES

Barekeng, 2023
A bicyclic graph is a type of graph that consists of exactly two cycles. A cycle is a graph that is a closed path where no vertices are repeated except the first and last vertices which are the same.
Aditya Ambarwati, Vira Hari Krisnawati
doaj   +1 more source

Rationally Designed Bicyclic Peptides Prevent the Conversion of Aβ42 Assemblies Into Fibrillar Structures

Frontiers in Neuroscience, 2021
There is great interest in drug discovery programs targeted at the aggregation of the 42-residue form of the amyloid β peptide (Aβ42), since this molecular process is closely associated with Alzheimer’s disease.
Tatsuya Ikenoue, Francesco A. Aprile, Francesco A. Aprile, Pietro Sormanni, Michele Vendruscolo   +4 more
doaj   +1 more source

Enhancing the Bioactivity of Bicyclic Peptides Targeted to Grb7-SH2 by Restoring Cell Permeability

Biomedicines, 2022
The development of peptide inhibitors against intracellular targets depends upon the dual challenge of achieving a high affinity and specificity for the target and maintaining cellular permeability for biological activity.
Natasha P. Sturre, Rhys N. Colson, Neelam Shah, Gabrielle M. Watson, Xue Yang, Matthew C. J. Wilce, John T. Price, Jacqueline A. Wilce   +7 more
doaj   +1 more source

The Chemistry and Biology of Cyclophostin, the Cyclipostins and Related Compounds

Molecules, 2019
Cyclophostin, the cyclipostins and the salinipostins are structurally related cyclic enolphosphate natural products. This mini review describes their isolation, synthesis and biological activities.
Christopher D. Spilling
doaj   +1 more source

Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli

Biomolecules, 2020
Resistance to β-lactam antibacterials, importantly via production of β-lactamases, threatens their widespread use. Bicyclic boronates show promise as clinically useful, dual-action inhibitors of both serine- (SBL) and metallo- (MBL) β-lactamases.
Pauline A. Lang, Anete Parkova, Thomas M. Leissing, Karina Calvopiña, Ricky Cain, Alen Krajnc, Tharindi D. Panduwawala, Jules Philippe, Colin W. G. Fishwick, Peteris Trapencieris, Malcolm G. P. Page, Christopher J. Schofield, Jürgen Brem   +12 more
doaj   +1 more source

Crystal structures of two bicyclo[5.1.0]octanes: potassium trans-bicyclo[5.1.0]octane-4-carboxylate monohydrate and cis-bicyclo[5.1.0]octan-4-yl 4-bromobenzenesulfonate

Acta Crystallographica Section E: Crystallographic Communications, 2017
The crystal structures of the trans-fused compound potassium trans-bicyclo[5.1.0]octane-4-carboxylate monohydrate, K+·C9H13O2−·H2O, (I), and of cis-bicyclo[5.1.0]octan-4-yl 4-bromobenzenesulfonate, C14H17BrO3S, (II), have been determined.
Peter W. R. Corfield, Richard A. Kershaw
doaj   +1 more source