Results 161 to 170 of about 1,962 (215)

Integrative Peptide Drug Development: Chemical Engineering, AI-Driven Design, and Cell-Penetrating Peptides. [PDF]

Pharmaceutics
Jang YE, Kwon M, Kwon CW, Kim SG, Hwang JS, George NP, Paik SR, Misra S, Basith S, Sheen SS, Lee G.   +10 more
europepmc   +1 more source

Preclinical evaluation of CPL423: a novel potent small-molecule inhibitor of TAM family and FLT3 kinase for cancer therapy. [PDF]

Front Pharmacol
Mikołajczyk A, Popiel D, Jastrzębska K, Wiernicki B, Mituła F, Janusz A, Dominowski J, Górka M, Kornatowski T, Hucz-Kalitowska J, Teska-Kamińska M, Smuga D, Delis M, Kamecki K, Maliszewski P, Yamani A, Dubiel K, Pieczykolan J, Wieczorek M.   +18 more
europepmc   +1 more source

An exhaustive cell-based screen coupled with an intracellular-induced lux-based reporter identified bioactive molecules that inhibit host cell infection by intracellular pathogens. [PDF]

Front Cell Infect Microbiol
Adani B, Plotnikov A, Lueken L, Shomer I, Shurrush K, Meyer N, Künnemann K, Kellermann M, Margulies D, Grassl GA, Hensel M, Barr HM, Gal-Mor O.   +12 more
europepmc   +1 more source

Computational Design of a Bicyclic Peptide Inhibitor Targeting the ICOS/ICOS-L Protein-Protein Interaction. [PDF]

Chem Biol Drug Des
Calvo-Barreiro L, Secor M, Damjanovic J, Abdel-Rahman SA, Lin YS, Gabr M.   +5 more
europepmc   +1 more source

Exploration of Antiplasmodium Chemical Space Identifies New Inhibitors of β-Hematin Formation from Areas of Enrichment. [PDF]

ChemMedChem
Thibaud JL, Myburgh DC, Sandlin RD, Fong KY, Garnie LF, Wicht KJ, Kuter D, Wright DW, Egan TJ, de Villiers KA.   +9 more
europepmc   +1 more source

Intranasal Delivery of Curcumin-Loaded Pure Drug Self-Assembled Lipid-Based Nanoparticles for Targeted Therapy of Depression. [PDF]

Int J Nanomedicine
Chen T, Liu X, Li D, Cheng Z, Zheng X, Yu Z.   +5 more
europepmc   +1 more source

A network-driven computational framework for identifying FDA-approved drug repurposing across heterogeneous brain cancers. [PDF]

Front Mol Biosci
Prakash O.
europepmc   +1 more source

Network Pharmacology-Serum Metabolomics Integration Identifies Key Targets, Biomarkers and Mechanism of Sendeng-4 in Rheumatoid Arthritis Therapy. [PDF]

Int J Gen Med
Zhou F, Li J, Zhou Y, Zhang X, Luo J, Li X, Sun W, Zhang Q, Li M.   +8 more
europepmc   +1 more source

Optimization of 4-Amino-2-Pyridone Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9: Integrating Structure-Activity and Structure-Metabolism Relationships. [PDF]

ChemMedChem
Giannessi L, Lupo MG, Ugolotti M, Papotti B, Mattina B, Martina MG, Demurtas A, Padula C, Nicoli S, Crescenzio M, Ferri N, Zimetti F, Radi M.   +12 more
europepmc   +1 more source