Results 51 to 60 of about 2,953,844 (279)

The implications of programmatic working on bid/no-bid decisions of contractors

open access: yes, 2023
Contractors increasingly have to reconsider the trade-off process in bid/no-bid decisions for tenders, due to changing procurement practices of public clients. Whereas public clients used to procure single projects, a shift is observed towards the procurement of programmes. Since programmes pose different characteristics than projects, project-oriented
Pap, Mirko   +2 more
openaire   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

Fundación Grupo Puntacana - BID Lab

open access: yes, 2023
Audiovisual sobre las distintas iniciativas emprendidas en el contexto del proyecto «Modelo de Economía Circular para Desechos Orgánicos en Zonas Turísticas», ejecutado por la Fundación Grupo Puntacana con un acuerdo con el Laboratorio de Innovación del ...
BID Lab, Fundación Grupo Puntacana
core  

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

open access: yesFEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Impact of Contractors’ Bidding Strategies on Bid Success in the Nigeria Construction Industry

open access: yesInternational Journal of Built Environment and Sustainability, 2017
Several types of researches have been carried out prior to the new millennium on the subject of bidding strategies in the construction industry. Today, organizations are faced with a very complex decision of bid/no-bid because it requires the assessment ...
Tolulope Samuel Fawale   +1 more
doaj   +1 more source

Factors affecting the bid/no bid decision in the Palestinian construction industry

open access: yesJournal of Financial Management of Property and Construction, 2010
PurposeThe purpose of this paper is to identify and rank the factors that affect the bid/no bid decision according to their relative importance from the perspective of the contracting parties operating in the Gaza Strip, Palestine.Design/methodology/approachThe objectives of this research were investigated through a postal questionnaire, which covered ...
Enshassi, A, Mohamed, S, El Karriri, A
openaire   +3 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Bidding factors in procurements of design documentation

open access: yesBudownictwo i Architektura, 2014
The present study described a group of factors that may influence the decision to participate in a tender, when the subject of the order is the preparation of design documentation.
Agnieszka Leśniak
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

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