Results 71 to 80 of about 2,953,844 (279)

Performance analysis of reverse auction mechanisms based on Petri nets

Advances in Mechanical Engineering, 2017
As a methodology of resource location and allocation, reverse auctions are one of the most important activities in supply chains. There are four main auction mechanisms in auction theory, ascending-bid auctions, descending-bid auctions, first-price and ...
Xiaodan Zhang, Zhiwu Li, Yun Huang, Huajun Tang   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Framework to Facilitate Bid/No Bid Decision Making of the Contracting Organisations in Sri Lanka

, 2022
The process of bidders submitting offers for the completion of construction projects is known as construction bidding. Contractors frequently acquire projects through competitive bidding, and the decision to bid or not to bid is a critical step in that ...
Gamage, I.S., Perera, B.A.K.S.
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A response to information criterion-based clustering with order-restricted candidate profiles in short time-course microarray experiments

BMC Bioinformatics, 2009
Background For gene expression data obtained from a time-course microarray experiment, Liu et al. 1 developed a new algorithm for clustering genes with similar expression profiles over time.
Umbach David M, Peddada Shyamal D, Harris Shawn F   +2 more
doaj   +1 more source

Function of BID - a molecule of the bcl-2 family - in ischemic cell death in the brain [PDF]

, 2002
Mitochondrial mechanisms, particularly the release of cytochrome c, play a role in the death of nerve and glial cells in cerebral ischemia. We have currently investigated whether BID, a proapoptotic molecule of the bcl-2 family and promoter of the ...
Amin-Hanjani, Sepideh, Qiu, Jianhua, Moskowitz, Michael A., Zinkel, Sandra, Korsmeyer, Stanley J., Plesnila, Nikolaus   +5 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Learning Environmental Parameters For The Design Of Optimal English Auctions With Discrete Bid Levels [PDF]

, 2005
In this paper we consider the optimal design of English auctions with discrete bid levels. Such auctions are widely used in online internet settings and our aim is to automate their configuration in order that they generate the maximum revenue for the ...
David, E, Schiff, J, S. Kraus, Jennings, N. R., Rogers, A, N. R. Jennings, J. Schiff, A. Rogers, E. David, Jennings, NR, Kraus, S   +10 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

AI-Assisted Game Theory Approaches to Bid Pricing Under Uncertainty in Construction

AppliedMath
The construction industry is inherently marked by high uncertainty levels driven by its complex processes. These relate to the bidding environment, resource availability, and complex project requirements.
Joas Serugga
doaj   +1 more source