Results 81 to 90 of about 3,237,044 (306)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Multi-time scale bidding strategy for virtual power plant markets based on hierarchical partition control

Zhongguo dianli
To enhance the economic efficiency and coordination capability of virtual power plant (VPP) in electricity markets, this paper proposes a multi-timescale bidding strategy based on hierarchical and zonal regulation.
Feng GAO, Lili HUANG, Jie CHEN, Song LU, Mingnan LI   +4 more
doaj   +1 more source

Optimal strategies for bidding agents participating in simultaneous Vickrey auctions with perfect substitutes [PDF]

, 2007
We derive optimal strategies for a bidding agent that participates in multiple, simultaneous second-price auctions with perfect substitutes. We prove that, if everyone else bids locally in a single auction, the global bidder should always place non-zero ...
Byde, A, Byde, Andrew, Jennings, Nick, Gerding, E, Dash, Rajdeep, Gerding, Enrico, Jennings, N, Dash, R   +7 more
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Data-Driven Chance-Constrained Capacity Offering for Wind-Electrolysis Joint Systems

IEEE Open Access Journal of Power and Energy
An alkaline water electrolyzer (AWE) that converts surplus electricity from fluctuating power of a wind farm (WF) is a promising technology for large-scale and cost-effective hydrogen production.
Xuemei Dai, Chunyu Chen, Bixing Ren, Shengfei Yin   +3 more
doaj   +1 more source

Gaussian Residual Bidding Based Coalition for Two-Settlement Renewable Energy Market

IEEE Access, 2018
To stabilize the output variability of renewable energy sources (RESs), distributed RESs can be aggregated and treated as any other conventional generators in the existing electricity markets.
Seunghyoung Ryu, Sunghwan Bae, Jong-Uk Lee, Hongseok Kim   +3 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Rational bidding using reinforcement learning: an application in automated resource allocation [PDF]

, 2008
The application of autonomous agents by the provisioning and usage of computational resources is an attractive research field. Various methods and technologies in the area of artificial intelligence, statistics and economics are playing together to ...
Borissov, Nikolay, Dirk Neumann, Wirström, Niklas, Neumann, Dirk, Anandasivam, Arun, Arun Anandasivam, Wirström, Niklas,, Niklas Wirström, Nikolay Borissov   +8 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source