Results 181 to 190 of about 6,021 (251)

When NCX switches sides: Experimental and computational insights into Ca2+ regulation in the heart

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Due to its presence inside the dyadic cleft, Na+/Ca2+ exchanger (NCX) builds a functional unit together with L‐type calcium channels and ryanodine receptors in the dyadic cleft. NCX acts bidirectionally (forward and reverse mode) dependent on extracellular calcium ([Ca2+]o) and sodium ([Na+]o) concentrations and the membrane ...
Wilhelm Neubert   +6 more
wiley   +1 more source

Voltage‐gated potassium channels mediate thyroid hormone control of skeletal muscle excitability

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Thyroid hormone (TH)‐dependent remodelling of potassium (K+) channel networks regulates skeletal muscle (SkM) excitability. Triiodothyronine (T3), locally generated from thyroxine (T4) by type 2 deiodinase (D2), binds thyroid hormone receptors (TRα/β) and modulates transcription via thyroid response elements (TREs).
Annarita Nappi   +12 more
wiley   +1 more source

Broadening horizons: Pathogenesis and therapeutics of renal ciliopathies

open access: yesJournal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
This review elucidates the molecular mechanisms and aberrant signaling pathways in renal ciliopathies, links genetic heterogeneity to clinical phenotypes, and lays a theoretical basis for prenatal diagnosis and novel therapies. Abstract Renal ciliopathies encompass a spectrum of genetic disorders arising from structural or functional impairments of ...
Qiaowei Zhang   +7 more
wiley   +1 more source

Artificial Intelligence Resources for the Screening of Titles and Abstracts in Systematic Reviews: A Scoping Review

open access: yesCochrane Evidence Synthesis and Methods, Volume 4, Issue 5, September 2026.
ABSTRACT Introduction Artificial intelligence (AI) is a branch of technology enabling machines to emulate complex human skills; it can also entail problem‐solving using bioinspired methods. It is used for automating systematic literature reviews (SLR), that is, defining a clinical question, locating relevant literature, preliminary screening, study ...
Ana M. Barragán   +5 more
wiley   +1 more source

Entropy‐Driven Innovations: Entropy Stabilized Oxides for High‐Performance Next‐Generation Lithium–Sulfur Batteries

open access: yesENERGY &ENVIRONMENTAL MATERIALS, Volume 9, Issue 5, September 2026.
This article explores high‐entropy‐stabilized oxides (HEOs) as novel functional materials for addressing critical issues in lithium–sulfur (Li–S) batteries, including lithium polysulfide (LPS) shuttling, inadequate conductivity, and slow redox kinetics.
Hassan Raza   +10 more
wiley   +1 more source

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