Results 121 to 130 of about 32,074 (266)

Estrone‐α‐2‐Deoxy‐Glucoside as a Targeted Therapy for Triple‐Negative Breast Cancer: Aromatase Inhibition and Cytotoxicity

Chemical Biology &Drug Design, Volume 107, Issue 2, February 2026.
Estrone‐α‐2DG, synthesized via a one‐pot multi‐enzyme system, selectively inhibits aromatase (IC50 = 0.101μM) and triple negative breast cancer cells (IC50 = 20.46 μM), offering a dual function therapeutic scaffold. ABSTRACT Aromatase inhibitors (AIs) are vital in the treatment of estrogen‐dependent breast cancer, especially in postmenopausal women. In
Tzu‐Yu Huang, Meng‐Ru Wang, Feng‐Pai Chou, Sheng‐Cih Huang, Po‐Yun Hsiao, Tung‐Kung Wu   +5 more
wiley   +1 more source

Extracellular vesicles of Bifidobacterium longum reverse the acquired carboplatin resistance in ovarian cancer cells via p53 phosphorylation on Ser15

Kaohsiung Journal of Medical Sciences
We previously found that the relative abundance of Bifidobacterium was increased after chemotherapy; however, the role of Bifidobacterium longum in chemotherapeutic drug resistance in ovarian cancer (OVC) remains unclear.
Yun‐Long Fan, Jia‐Xi Jin, Jun Zhu, Hai‐Bo Ruan, Jin‐Qun Huang   +4 more
doaj   +1 more source

Gut bifidobacteria populations in human health and aging

Frontiers in Microbiology, 2016
The intestinal microbiota has increasingly been shown to have a vital role in various aspects of human health. Indeed, several studies have linked alterations in the gut microbiota with the development of different diseases.
Silvia Arboleya, Silvia Arboleya, Claire Watkins, Claire Watkins, Catherine Stanton, Catherine Stanton, Paul Ross, Paul Ross   +7 more
doaj   +1 more source

Structural and Thermodynamic Analyses of Solute-binding Protein from Bifidobacterium longum Specific for Core 1 Disaccharide and Lacto-N-biose I [PDF]

, 2008
Ryuichiro Suzuki, Jun Wada, Takane Katayama, Shinya Fushinobu, Takayoshi Wakagi, Hirofumi Shoun, Hayuki Sugimoto, Akiyoshi Tanaka, Hidehiko Kumagai, Hisashi Ashida, Motomitsu Kitaoka, Kenji Yamamoto   +11 more
openalex   +1 more source

Two extracellular α-arabinofuranosidases are required for cereal-derived arabinoxylan metabolism by Bifidobacterium longum subsp. longum

Gut Microbes
Members of the genus Bifidobacterium are commonly found in the human gut and are known to utilize complex carbohydrates that are indigestible by the human host. Members of the Bifidobacterium longum subsp.
Lisa Friess, Francesca Bottacini, Fionnuala M. McAuliffe, Ian J. O’Neill, Paul D. Cotter, Ciaran Lee, Jose Munoz-Munoz, Douwe van Sinderen   +7 more
doaj   +1 more source

Effect of Bifidobacterium upon Clostridium difficile growth and toxicity when co-cultured in different prebiotic substrates

Frontiers in Microbiology, 2016
The intestinal overgrowth of Clostridium difficile, often after disturbance of the gut microbiota by antibiotic treatment, leads to C. difficile infection (CDI) which manifestation ranges from mild diarrhoea to life-threatening conditions. The increasing
Lorena Valdés Varela, Ana M. Hernández-Barranco, Patricia eRuas-Madiedo, Miguel eGueimonde   +3 more
doaj   +1 more source

Kajian Karakteristik Minuman Sinbiotik Pisang Kepok (Musa Paradisiaca Forma Typical) Dengan Menggunakan Starter Lactobacillus Acidophillus Ifo 13951 Dan Bifidobacterium Longum Atcc 15707 [PDF]

, 2012
Penelitian ini dilakukan untuk mengetahui karakteristik minuman sinbiotik buah pisang kepok yang meliputi total bakteri probiotik,karakteristik fisikokimia dan karakteristik organoleptik.
Umam, M. F. (Muhammad), Utami, R. (Rohula), Widowati, E. (Esti)   +2 more
core  

Exploiting neonatal host-bifidobacteria interactions to promote intestinal pathogen tolerance and barrier function: Bifidobacterium longum subsp. infantis outperforms Bifidobacterium adolescentis in anti-Salmonella activity and maintenance of intestinal homeostasis

Food Science and Human Wellness
Bifidobacterium longum subsp. infantis and Bifidobacterium adolescentis play important roles in the guts of infants and adolescents, respectively. In this study, using a neonatal rat model, we compared the protective effects of these 2 bifidobacterial ...
Chunxiu Lin, Shunhe Wang, Min Guo, Wentian Li, Jiayin Qiu, Yonghua Zhou, Hao Zhang, Wei Chen, Gang Wang   +8 more
doaj   +1 more source

Cloned Cytosine Deaminase Gene Expression ofBifidobacterium longumand Application to Enzyme/Pro-drug Therapy of Hypoxic Solid Tumors [PDF]

, 2002
Toshiyuki Nakamura, Takayuki Sasaki, Maiko Fujimori, Kazuyuki Yazawa, Yasunobu Kano, Jun Amano, Shun’ichiro Taniguchi   +6 more
openalex   +1 more source

Global transcriptome analysis of the heat shock response of Bifidobacterium longum [PDF]

, 2017
Bifidobacteria are natural inhabitants of the human gastrointestinal tract and have been widely used as functional foods in different products. During industrial processing, bacterial cells undergo several stresses that can limit large-scale production ...
Arigoni, Fabrizio, Barretto, Caroline, Cuanoud, Gabriella, Delley, Michèle, Giliberti, Gabriele, Lariani, Sofiane, Pessi, Gabriella, Rezzonico, Enea   +7 more
core