Results 141 to 150 of about 556,712 (359)

Utilizing Causal Network Markers to Identify Tipping Points ahead of Critical Transition

open access: yesAdvanced Science, EarlyView.
The study proposes a causal network markers (CNMs) framework to identify early‐warning signals preceding critical transitions. It validates CNMs on various computational benchmark models and real‐world datasets, demonstrating higher accuracy and flexibility compared to existing approaches.
Shirui Bian   +4 more
wiley   +1 more source

Endothelial BMP6 Drives Hemodynamic‐Dependent VSMCs Calcification in Carotid Atherosclerosis

open access: yesAdvanced Science, EarlyView.
The study demonstrates that endothelial cell (EC)‐derived BMP6 promotes the osteogenic differentiation of vascular smooth muscle cells (VSMCs) through cell‐cell interactions. Additionally, the researchers preliminarily explore the driving effect of hemodynamic factors on BMP6‐induced calcification and reveal the regulatory role of KLF4 on BMP6.
Shen Li   +12 more
wiley   +1 more source

Identifying Tipping Points during Healthy Brain Aging through Single‐Nucleus Transcriptomic Analysis

open access: yesAdvanced Science, EarlyView.
This study applies single‐nucleus transcriptomics and systems dynamics to uncover nonlinear aging patterns in healthy human brains. By introducing dynamic network biomarker theory, the authors identify a critical tipping point at ages 56–60 during aging, and highlight glial instability as a key mediator.
Peiru Wu   +9 more
wiley   +1 more source

Biomimetic Thermal Safety Strategies in Batteries for Electric Vehicles: from Biological Principles to Engineering Approaches

open access: yesAdvanced Science, EarlyView.
Biological principles derived from natural structures and functions inspire novel biomimetic strategies for battery thermal safety. This review summarizes applications of biomimetic concepts in preventing thermal runaway, highlighting design strategies that enhance thermal safety protection.
Weifeng Li   +7 more
wiley   +1 more source

Spatial Transcriptomics Reveals Transcriptomic and Immune Microenvironment Reprogramming during Thyroid Carcinoma Dedifferentiation

open access: yesAdvanced Science, EarlyView.
Spatial transcriptomic analysis of Anaplastic thyroid carcinoma (ATC)‐differentiated thyroid carcinoma (DTC) coexisting tumors reveals that coexisting DTC regions with ATC‐like genomic alterations undergo sequential transcriptomic reprogramming and immune microenvironment remodeling, ultimately evolving into a full ATC pathological phenotype.
Kang Ning   +19 more
wiley   +1 more source

Phase‐Space Generalized Brillouin Zone For Spatially Inhomogeneous Non‐Hermitian Systems

open access: yesAdvanced Science, EarlyView.
A novel phase‐space generalized Brillouin zone (GBZ) framework to devised captures the interplay of spatial inhomogeneity and non‐local non‐Hermitian effects. This reveals new degrees of freedom such as jumps in the bifurcated GBZ, as well as new routes for topological protection, with potential applications in characterizing inhomogeneous or ...
Qingya Li, Hui Jiang, Ching Hua Lee
wiley   +1 more source

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