Results 111 to 120 of about 60,891 (313)

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Asymptotic analysis of a secondary bifurcation of the one-dimensional Ginzburg-Landau equations of superconductivity

, 2000
The bifurcation of asymmetric superconducting solutions from the normal solution is considered for the one-dimensional Ginzburg--Landau equations by the methods of formal asymptotics.
Chapman, Stephen, S. J. Chapman, Chapman, S. J., Chapman, SJ, Aftalion, Amandine, A. Aftalion, Aftalion, A   +6 more
core   +1 more source

Limit-point buckling analyses using solid, shell and solid–shell elements [PDF]

, 2011
In this paper, the recently-developed solid-shell element SHB8PS is used for the analysis of a representative set of popular limit-point buckling benchmark problems.
Farid Abed-Meraim, ABED-MERAIM, Farid, Killpack, Marc D., KILLPACK, Marc, Marc Killpack   +4 more
core   +1 more source

Interfacial Proton‐Relay Microenvironment Enables Self‐Driven Singlet Oxygen Generation under Neutral Conditions

Advanced Science, EarlyView.
An interfacial proton‐relay microenvironment at MoS2‐CuCl heterostructures enables selective O2 activation to 1O2 under neutral conditions. Electron‐deficient sulfur sites mediate proton transfer to Cu‐bound O2, accelerating *OOH hydrogenation while suppressing O─O bond cleavage, achieving stable, efficient pollutant removal.
Qiaoyu Gao, Xiaohui Dai, Jian Ye, Lili Li, Chenxiao Yu, Yuehan Jiang, Jiangdong Dai, Xiaohua Tian, Jun Zhao, Jianming Pan   +9 more
wiley   +1 more source

Overview of the theoretical relations between necking and strain localization criteria. [PDF]

, 2013
Many criteria have been developed during last decades to predict diffuse or localized necking and shear banding. The lack of confrontation of these models with each other on relevant applications makes their choice difficult for the designer.
ALTMEYER, Guillaume, BALAN, Tudor, ABED-MERAIM, Farid   +2 more
core  

Stability calculations for piecewise-smooth delay equations

, 2008
This paper describes a new method for computing the stability of nonsmooth periodic orbits of piecewise-smooth dynamical systems with delay. Stability computations for piecewise-smooth dynamical systems without delay have previously been performed using ...
Barton, DAW
core   +1 more source

Unlocking Strength‐Toughness Dilemma in High‐Entropy Borides by Intragranular Microstructural Reconstruction

Advanced Science, EarlyView.
An extreme non‐equilibrium process combining heavy direct current sintering and TiSi2 addition is used to construct intragranular energy dissipation units within high‐entropy boride ceramics to overcome the strength‐toughness trade‐off. The resulting ceramic demonstrates attractive mechanical properties with a flexural strength of 887 MPa and a ...
Yingjun Liu, Yuhan Yao, Yufei Zu, Zhaofu Zhang, Yang Zhang, Hongfeng Dong, Nan Zhang, Wuhao Cao, Lehao Liu, Yuan Hu, Ruiheng An, Wenhu Li, Luyi Zhu, Taotao Ai   +13 more
wiley   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Numerical detection of bifurcation point in the curve

, 2015
We are presenting a numerical method which detects the presence and position of a  bifurcation simplex, the regular $(k+1)$-dimensional simplex, which may be considered as "fat bifurcation point", in the curve of zeroes of the $C^1$ map $f:{\mathbb ...
Gulgowski, Jacek
core   +1 more source

In‐Process Magnetization for 3D Printing of Magnetorheological Elastomer with Heterogeneous Magnetic Profile for Anisotropic Actuation

Advanced Science, EarlyView.
Fully programmable, in‐process 3D magnetization integrated with multi‐material printing enables soft magnetic systems with precise actuation and sensing. Discrete and continuous magnetization profiles drive bending, morphing, and locomotion, demonstrated through strain‐sensing elements, dragonfly‐inspired wings, octopus‐like tentacles, and a serpentine
Phillip Glass, David Hassouna, Udena Epitawala Arachchige, Hyeon Yun Jeong, Sung Hyun Park, Daeha Joung   +5 more
wiley   +1 more source