Results 131 to 140 of about 3,434,319 (342)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Chromosome-level genome assembly and annotation of the Yunling cattle with PacBio and Hi-C sequencing data

Scientific Data
Yunling cattle is a new breed of beef cattle bred in Yunnan Province, China. It is bred by crossing the Brahman, the Murray Grey and the Yunnan Yellow cattle.
Zaichao Wei, Lilian Zhang, Lutao Gao, Jian Chen, Lin Peng, Linnan Yang   +5 more
doaj   +1 more source

Hybrid Attention Fusion Embedded in Transformer for Remote Sensing Image Semantic Segmentation

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
In the context of fast progress in deep learning, convolutional neural networks have been extensively applied to the semantic segmentation of remote sensing images and have achieved significant progress.
Yan Chen, Quan Dong, Xiaofeng Wang, Qianchuan Zhang, Menglei Kang, Wenxiang Jiang, Mengyuan Wang, Lixiang Xu, Chen Zhang   +8 more
doaj   +1 more source

A bigger bang for your buck: Enhanced access to your chick data [PDF]

, 2004
Parker B. Antin, Gary C. Schoenwolf, Nancy A. Olsen   +2 more
openalex   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

View-label driven cross-space structure alignment for incomplete multi-view partial multi-label classification

Journal of King Saud University: Computer and Information Sciences
Despite significant advancements in multi-view multi-label learning driven by its broad applicability, real-world scenarios frequently suffer from dual incompleteness in both view and label spaces due to data acquisition uncertainties. The incompleteness
Shenrun Ding, Jiarui Chen, Tongwei Gao, Yinghao Ye, Xiaohuan Lu   +4 more
doaj   +1 more source

AANet: Adaptive Attention Networks for Semantic Segmentation of High-Resolution Remote Sensing Imagery

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Contextual information can effectively aid deep-learning models in extracting interclass and intraclass difference features in remote sensing images.
Yan Chen, Qianchuan Zhang, Xiaofeng Wang, Quan Dong, Menglei Kang, Wenxiang Jiang, Mengyuan Wang, Lixiang Xu, Chen Zhang   +8 more
doaj   +1 more source

Modelling Amazonian forest eddy covariance data: a comparison of big leaf versus sun/shade models for the C-14 tower at Manaus I. Canopy photosynthesis [PDF]

, 2006
Lina M. Mercado, Jon Lloyd, Bob Carswell, Yadvinder Malhi, Patrick Meir, Antônio Donato Nobre   +5 more
openalex   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source