Results 141 to 150 of about 3,434,319 (342)

A refined lion optimizer for deep learning

open access: yesScientific Reports
Optimization algorithms play a fundamental role in training neural networks. The optimizer focuses on the updating weights of momentum and velocity on learning rates and losses, furthermore the complexity of the optimizer and the quantity of updated ...
Jian Rong   +4 more
doaj   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

Siamese network with squeeze-attention for incomplete multi-view multi-label classification

open access: yesComplex & Intelligent Systems
Multi-view multi-label classification (MvMLC) has garnered significant interest because of its ability to handle complex datasets. However, the inherent complexity of real-world data often results in incomplete views and missing labels, which limit the ...
Mengqing Wang   +4 more
doaj   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

Big Data, a Big Mistake? [PDF]

open access: yesEuropean Journal of Vascular and Endovascular Surgery, 2019
Anne Lejay, Nabil Chakfe
openaire   +3 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

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