Results 241 to 250 of about 25,203,054 (312)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Application study of an artificial intelligence and big data-based personalized chronic disease management model for diabetes patients. [PDF]

Front Public Health
Xin M, Yao Y, Huang P, Li Q.
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Utilizing big data and artificial intelligence to improve the cross-border trade english education. [PDF]

PLoS One
Pang Y, Ma Q.
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Correction: NanoBERTa-ASP: predicting nanobody paratope based on a pretrained RoBERTa model

BMC Bioinformatics
Shangru Li, Xiangpeng Meng, Rui Li, Bingding Huang, Xin Wang   +4 more
doaj   +1 more source

A big data approach to artificial intelligence driven predictive modelling for optimizing material properties in additive manufacturing. [PDF]

Sci Rep
Li W, Cai Z, Bao K, Wang L, Ma J, Wang L, Gao F, Yang D, Zhang R.   +8 more
europepmc   +1 more source

Ephrin Receptors and Ephrin Ligands in Uveal Melanoma: A Big Data Analysis Using Web Resources. [PDF]

Int J Mol Sci
Mandrakis G, Flessa CM, Keratsa P, Zaravinos A, Theocharis S, Sykaras AG.   +5 more
europepmc   +1 more source

ThreatFedChainAI: an adaptive edge blockchain architecture for big data-driven threat analytics in IoT networks. [PDF]

Sci Rep
Ashwini N, Dava S, Phanindra AR, Ranjith Kumar G, Rajkumar KV, Sravanthi N.   +5 more
europepmc   +1 more source