Results 261 to 270 of about 26,034,833 (395)
Opportunities, challenges and Countermeasures for the development of China's sports industry in the era of big data [PDF]
, 2018 Chen Feng-cai
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Nanomaterials in Drug Delivery: Leveraging Artificial Intelligence and Big Data for Predictive Design. [PDF]
Int J Mol SciHan Y, Kim DH, Pack SP.
europepmc +1 more source
Critical analysis of Big Data challenges and analytical methods
, 2017 U. Sivarajah +3 more
semanticscholar +1 more source
Predicting the Future - Big Data, Machine Learning, and Clinical Medicine.
New England Journal of Medicine, 2016 Z. Obermeyer, E. Emanuel
semanticscholar +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Analyzing adolescent mental health: Correlates of depression and anxiety through big data analytics. [PDF]
Digit HealthLi Q +6 more
europepmc +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Security situation awareness algorithm of network information transmission based on big data. [PDF]
Sci RepWang X, Zhou Z.
europepmc +1 more source