Results 71 to 80 of about 3,434,319 (342)

A service composition method using improved hybrid teaching learning optimization algorithm in cloud manufacturing

Journal of Cloud Computing: Advances, Systems and Applications, 2022
In the cloud manufacturing process, service composition can combine a single service into a complex service to meet the task requirements. An efficient service composition strategy is crucial, as it affects the efficiency of resource and capacity sharing
Jun Zeng, Juan Yao, Min Gao, Junhao Wen
doaj   +1 more source

Big Data\u27s Other Privacy Problem [PDF]

, 2014
Big Data has not one privacy problem, but two. We are accustomed to talking about surveillance of data subjects. But Big Data also enables disconcertingly close surveillance of its users.
Grimmelmann, James
core   +1 more source

The big challenges of big data [PDF]

Nature, 2013
As they grapple with increasingly large data sets, biologists and computer scientists uncork new bottlenecks.
openaire   +3 more sources

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Big Data and medicine: a big deal? [PDF]

Journal of Internal Medicine, 2018
AbstractBig Data promises huge benefits for medical research. Looking beyond superficial increases in the amount of data collected, we identify three key areas where Big Data differs from conventional analyses of data samples: (i) data are captured more comprehensivelyrelativeto the phenomenon under study; this reduces some bias but surfaces important ...
V. Mayer‐Schönberger, E. Ingelsson
openaire   +3 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

The Carbon Emission Reduction Effect and Spatio-Temporal Heterogeneity of the Science and Technology Finance Network: The Combined Perspective of Complex Network Analysis and Econometric Models

Systems
With the active promotion of the “carbon peaking and carbon neutrality” goals, science and technology finance (STF) is the important driving force of low-carbon development, and financial networks facilitate the aggregation and transformation of ...
Juan Liang, Rui Ding, Xinsong Ma, Lina Peng, Kexin Wang, Wenqian Xiao   +5 more
doaj   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

ANALYZING BIG DATA WITH DECISION TREES [PDF]

, 2014
ANALYZING BIG DATA WITH DECISION ...
Leong, Lok Kei
core   +1 more source