Results 181 to 190 of about 1,284,460 (362)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Analyzing adolescent mental health: Correlates of depression and anxiety through big data analytics. [PDF]

Digit Health
Li Q, Guo X, Zhou H, Xu Z, Xu S, Xu G, Zhang JJ.   +6 more
europepmc   +1 more source

Exploring the influence of circular economy on big data analytics and supply chain resilience nexus: A structural equation modeling approach

Samia Islam, S.Z. Hassan, Sourav Hossain, Tazim Ahmed, Chitra Lekha Karmaker, A.B.M. Mainul Bari   +5 more
openalex   +1 more source

Big Data analytics for Advanced Viticulture

, 2021
Jitali Patel, Ruhi Patel, Saumya Shah, Jigna Patel   +3 more
openalex   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Using AI and big data analytics to support entrepreneurial decisions in the digital economy. [PDF]

Sci Rep
Cao Y.
europepmc   +1 more source

A Big Data Analytics Architecture Framework for the Production and International Trade of Oilseeds and Textiles in Sub-Saharan Africa (SSA)

, 2023
Gabriel Kabanda
openalex   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Artificial intelligence in hepatopathy diagnosis and treatment: Big data analytics, deep learning, and clinical prediction models. [PDF]

World J Gastroenterol
Sun JR, Sun XN, Lu BJ, Deng BC.
europepmc   +1 more source

Predictors of outpatients’ no-show: big data analytics using apache spark [PDF]

, 2020
Tahani Daghistani, Huda AlGhamdi, Riyad Alshammari, Raed H. AlHazme   +3 more
openalex   +1 more source