Results 111 to 120 of about 115,029 (313)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Big data technology and near real-time production tracking to improve small-scale fisheries management [PDF]
, 2022 National level uptake of the innovation by the government of Timor-Leste in May 2019 as their official fisheries monitoring system. 359 solar-powered tracking devices were installed on fishing boats in Timor-Leste." plan to install 500 in ...
CGIAR Platform for Big Data in Agriculture
core
, 2017 CGIAR’s Big Data Platform aims to accelerate and enhance the impact of international agricultural research by enabling researchers to discover, analyze and visualize agricultural data on a large scale to generate rapid, actionable insights. A key aspiration is to build and nurture partnerships across CGIAR Centers and a variety of external partners to ...
openaire +1 more source
Fractional model analysis of COVID-19 spread based on big data platform. [PDF]
Heliyon, 2023 Li Y, Liu X.
europepmc +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Retracted: Analysis of Different College Music Education Management Modes Using Big Data Platform and Grey Theoretical Model. [PDF]
J Environ Public Health, 2023 Environmental And Public Health JO.
europepmc +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Analysis of the Construction of Big Data Platform in Scenic Spots to Increase the Number of Tourists: Taking Sports Group Performance as an Example. [PDF]
J Environ Public Health, 2022 Yu L, Hua L, Ding J.
europepmc +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source