Results 31 to 40 of about 7,223,865 (302)

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

open access: yesFEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva   +1 more
wiley   +1 more source

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

open access: yesFEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

The last five years of Big Data Research in Economics, Econometrics and Finance: Identification and conceptual analysis [PDF]

open access: yes, 2019
Today, the Big Data term has a multidimensional approach where five main characteristics stand out: volume, velocity, veracity, value and variety. It has changed from being an emerging theme to a growing research area.
Cobo Martín, Manuel Jesús   +4 more
core   +2 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Big-Bang Nucleosynthesis within the Scale Invariant Vacuum Paradigm [PDF]

open access: yesarXiv, 2023
The Scale Invariant Vacuum (SIV) paradigm is applied to the Big-Bang Nucleosynthesis using the known analytic expressions for the expansion factor $a$ and the plasma temperature $T$ as functions of the SIV time $\tau$ since the Big-Bang when $a(\tau=0)=0$.
arxiv  

Perfectionism and the Big Five: Conscientiousness predicts longitudinal increases in self-oriented perfectionism [PDF]

open access: yes, 2009
Findings from cross-sectional studies on the relationship between perfectionism and the Big Five personality traits demonstrate that conscientiousness shows significant positive correlations with self-oriented perfectionism, and neuroticism with socially
Allport   +34 more
core   +1 more source

Instagram addiction and the Big Five of personality: The mediating role of self-liking

open access: yesJournal of Behavioral Addictions, 2018
Background and aims Recent research has suggested that social networking site use can be addictive. Although extensive research has been carried out on potential addiction to social networking sites, such as Facebook, Twitter, YouTube, and Tinder, only ...
Kagan Kircaburun, M. Griffiths
semanticscholar   +1 more source

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

open access: yesFEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti   +3 more
wiley   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

open access: yesFEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy