Results 41 to 50 of about 2,723,374 (349)

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

The big five: Discovering linguistic characteristics that typify distinct personality traits across Yahoo! answers members [PDF]

, 2018
Indexación: Scopus.This work was partially supported by the project FONDECYT “Bridging the Gap between Askers and Answers in Community Question Answering Services” (11130094) funded by the Chilean Government.In psychology, it is widely believed that ...
Figueroa, A., Olivares, N., Vivanco, L.M.   +2 more
core   +1 more source

Establishing the associations between the Big Five personality traits and self-reported number of close friends: A cross-sectional and longitudinal study

Acta Psychologica, 2023
Close friends are important across the life span, who spend time together, provide support, and share happiness. But what determines the number of close friends one would have?
Weixi Kang
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Examining five-factor model personality traits among recently divorced Danes

Nordic Psychology
One of the main theoretical perspectives for understanding the mechanism responsible for the extensively reported mental and physical health disparities between divorcees and continuously married populations is the Selection Perspective. This perspective
Jenna Marie Strizzi, Ana Ciprić, Søren Sander, Gert Martin Hald, Camilla S. Øverup   +4 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Big data for monitoring educational systems [PDF]

, 2017
This report considers “how advances in big data are likely to transform the context and methodology of monitoring educational systems within a long-term perspective (10-30 years) and impact the evidence based policy development in the sector”, big data ...
Berendt, Bettina, Blakemore, Michael, Kern, Philippe, Littlejohn, Allison, Mitros, Piotr, Shacklock, Xanthe   +5 more
core   +1 more source

The High Five: Associations of the Five Positive Factors with the Big Five and Well-being

Frontiers in Psychology, 2017
The study of individual differences in positive characteristics has mainly focused on moral traits. The objectives of this research were to study individual differences in positive characteristics from the point of view of the layperson, including non ...
Alejandro C. Cosentino, Alejandro Castro Solano, Alejandro Castro Solano   +2 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source