Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Smoking behavior and nicotine dependence: the predictive role of personality traits. [PDF]
Front Public HealthAlqahtani JS.
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Big Thicket National Preserve and Big Thicket Association Anniversary Flyer
Schedule of events for the 25th anniversary of Big Thicket National Preserve and 35th anniversary of the Big Thicket Association, happening concurrentlyThe Big Thicket Collection contains materials relating to the conservation of the Big Thicket area of ...
Big Thicket National Preserve, U.S. National Park Service
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Does generative AI mean the "end of history" for pharmacovigilance automation? towards a framework for the future of human-AI systems. [PDF]
Front Drug Saf RegulWu L, Xu J, Dang O, Ball R.
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Canned goods at the North High street Big Bear location
, 1948 Canned goods at 1101 North High Street Big Bear location, in October of 1948. Big Bear is responsible for many innovations in the supermarket business. They were the first to introduce motorized counters that were controlled by the cashier.
Big Bear
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Timely Initiation of Breastfeeding and Associated Factors in 20 Sub-Saharan African Countries: Cross-Sectional Multilevel Analysis of Recent Demographic and Health Surveys. [PDF]
JMIR Pediatr ParentKassie TD +11 more
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Canned goods at the Toledo Big Bear location
, 1940 Canned goods at the 350 West Central Ave. Toledo, Ohio Big Bear location, in September of 1940. Big Bear is responsible for many innovations in the supermarket business.
Big Bear
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