Results 151 to 160 of about 205,796 (267)

Personality Traits and Attention in Israeli Older Adults: An Exploratory Study. [PDF]

Geriatrics (Basel)
Lufi D, Haimov I.
europepmc   +1 more source

Big Thicket Bulletin

, 1979
Bimonthly newsletter of the Big Thicket Association discussing news, events, and other updates related to the work of the group and the Big Thicket ...
Big Thicket Association
core  

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Body Size Trade-Offs Underpin Reproductive Success and Thermal Stress Tolerance in an Invasive Pest, the Small Hive Beetle. [PDF]

Ecol Evol
Adams B, Chen J, Amiri E.
europepmc   +1 more source

Big Thicket Reporter

, 2002
Bimonthly newsletter of the Big Thicket Association discussing news, events, and other updates related to the work of the group and the Big Thicket ...
Big Thicket Association
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Development and content validation of a health assessment item bank for regional health big data: a sequential mixed-methods approach. [PDF]

Health Qual Life Outcomes
Zhang Y, Chen H, Zhu W, Zhao G, Li Y, Sun H.   +5 more
europepmc   +1 more source

Big Thicket Reporter

, 2014
Quarterly newsletter of the Big Thicket Association discussing news, events, and other updates related to the work of the group and the Big Thicket ...
Big Thicket Association
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Agency and well-being. [PDF]

World Psychiatry
Seligman MEP.
europepmc   +1 more source