Results 131 to 140 of about 9,327,337 (301)
Man operating a computer at Big Bear stores
, 1962 Grocers Beacon, Special Edition on Big Bear. In 1934, an innovation in food retailing was introduced in Columbus when Wayne E. Brown opened the first self-service supermarket in central Ohio.
Big Bear
core +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Journal of Big HistoryAs Big History has institutionalized, calls have grown for a “new” Big History. This article argues instead for revitalization rather than replacement, identifying flexibility and accessibility as structural requirements for renewal. It begins by reassessing the threshold framework, arguing that its durability reflects built-in flexibility: thresholds ...
openaire +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Wayne E. Brown at Toledo Big Bear location
, 1950 Wayne E. Brown at toledo big bear location. In 1934, an innovation in food retailing was introduced in Columbus when Wayne E. Brown opened the first self-service supermarket in central Ohio. The name “Big Bear” was chosen because Brown felt it was catchy
Big Bear
core
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Office workers for Big Bear stores
, 1962 Grocers Beacon, Special Edition on Big Bear. In 1934, an innovation in food retailing was introduced in Columbus when Wayne E. Brown opened the first self-service supermarket in central Ohio.
Big Bear
core
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Bowman Dairy Company mascot "Bud Bowman" and "Big Bear" photograph
, 1930 Bowman Dairy Company mascot "Bud Bowman" and "Big Bear" standing outside the Buckeye Premium Stamp Redemption Center, Big Bear Store #1, Lane Avenue, Columbus, Ohio. The Lane Avenue store, which opened in 1934, was the first Big Bear store and the first
Big Bear
core
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source