Results 131 to 140 of about 205,796 (267)
Photograph of trained bear with handler for the Zanesville Big Bear store
, 1948 Black and white photograph of trained bear with handler for the Zanesville big bear store at 160 North Street, Zanesville, Ohio. This photograph was taken in June of 1948.
Big Bear
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Bear at the Graceland Shopping Center Big Bear location
, 1954 Graceland, Columbus, Ohio Wayne E. Brown at the Graceland Shopping Center Big Bear location. Big Bear is responsible for many innovations in the supermarket business. They were the first to introduce motorized counters that were controlled by the cashier.
Big Bear
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Parking lot and exterior of Graceland Shopping Center Big Bear location
, 1954 Black and white photograph of the parking lot and exterior of the Graceland Shopping Center Big Bear location in July of 1954. Supermarkets introduced many 'firsts' in the ratailing industry to their customers during these years: one-step shopping; new ...
Big Bear
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Farmer's residence on Big Bear Farms
, 1962 Black and white photograph of the farmer's residence on Big Bear Farms in Powell, Ohio. According to a letter, written by Wayne E. Brown, in December 1961, "At present two tenants are living in the houses on the farm and handle the cattle feeding and ...
Big Bear
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Wayne E. Brown at the Graceland Shopping Center Big Bear location
, 1954 Wayne E. Brown at the graceland Big Bear location. Big Bear is responsible for many innovations in the supermarket business. They were the first to introduce motorized counters that were controlled by the cashier.
Big Bear
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source