Results 121 to 130 of about 205,796 (267)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Color photograph of the Big Bear 1958 nerve center
, 1953 Color photo from Big Bear Stores annual report in 1958, showing the memory drum used in connection with the RAMAC computer. The description reads, "At left is the fabuous memory drum used in con-nection with the RAMAC equipment on which is recorded the ...
Big Bear
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COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Canned goods at the North High street Big Bear location
, 1948 Canned goods at 1101 North High Street Big Bear location, in October of 1948. Big Bear is responsible for many innovations in the supermarket business. They were the first to introduce motorized counters that were controlled by the cashier.
Big Bear
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Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Stacked cans display at Big Bear grocery store
, 1934 In 1934, an innovation in food retailing was introduced to Columbus when Wayne E. Brown opened the first self-service supermarket in central Ohio. Brown leased a 70,000 square foot building on Lane Avenue.
Big Bear
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, 2021 Quarterly newsletter of the Big Thicket Association discussing news, events, and other updates related to the work of the group and the Big Thicket ...
Big Thicket Association
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Canned goods at the Toledo Big Bear location
, 1940 Canned goods at the 350 West Central Ave. Toledo, Ohio Big Bear location, in September of 1940. Big Bear is responsible for many innovations in the supermarket business.
Big Bear
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Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source