Results 111 to 120 of about 205,796 (267)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Photograph of cattle at Big Bear Farms
, 1962 Black and white photograph of cattle and Big Bear stores President, Wayne E. Brown, at Big Bear Farms in Powell, Ohio. Big Bear Farms provided a good portion of the meats offered by the self service Big Bear chain stores. The farm was located near Powell,
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The Problem with the Concept of Complexity
Journal of Big HistoryThe concept of complexity is one of the most fundamental of big history fundamentals. The concept of complexity has great potential for understanding the shared qualities of otherwise disparate systems, explaining large-scale change, and comparing ...
Maximillian Barnett
doaj +1 more source
Dairy case at the Graceland Shopping Center Big Bear location
, 1954 Color photograph of the dairy case at the Graceland Big Bear location in July of 1954. Supermarkets introduced many 'firsts' in the ratailing industry to their customers during these years: one-step shopping; new merchandising gimmicks; many new ...
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Canned goods at the Newark Big Bear location
, 1940 Canned goods at the Newark, Ohio Big Bear location. This store opened on July 1, 1940 and was remodeled in September of 1962. Big Bear is responsible for many innovations in the supermarket business.
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Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
The natural science underlying big history. [PDF]
ScientificWorldJournal, 2014 Chaisson EJ.
europepmc +1 more source
Big Bear stores company common stock report
, 1957 Common Stock report for Big Bear stores. The cover reads, "325,000 shares Big Bear Stores Company Class A Common Stock Price: $10.00 per share. The Ohio Company Investments | 51 N. High St. CApital 1-4431 Columbus 15, Ohio.
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