Results 91 to 100 of about 9,327,337 (301)
Journal of Big History, 2019 The idea that our Universe emerged as a result of the extraordinary power of the Big Bang from singularity (i.e., a state of an infinitely small quantity and infinitely high concentration of matter) is still very popular today.
Leonid Grinin
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Leverage Big History Framework to Construct Big Future
The main purposes of this article are to modify the Big History framework to maximize its effectiveness and to resolve the many conflicts within our discipline.
Barry Borgerson
core +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
, 1930 Bud Bowman and Big Bear standing outside the Buckeye Premium Stamp Redemption Center, Big Bear Store #1, Lane Avenue, Columbus, Ohio. The Lane Avenue store, which opened in 1934, was the first Big Bear store and the first self-service supermarket in ...
Big Bear
core
Toward a Big History Interpretation of Religion
Journal of Big History, 2019 The word “religion” refers to a wide range of phenomena ranging from Tibetan Buddhism to the Prosperity Gospel. As a result, religion has accrued a “bewildering variety of definitions”. This essay, rather than asking the ontological question – “What kind
Ken Baskin
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
, 1962 Black and white photo of a Big Bear bakery, featured in the Grocers Beacon, Special Edition on Big Bear. Big Bear Bakeries, Inc. ("Bakery") owned and operated a central bakery in Columbus and manufactured and distributed fresh bread and pastery products ...
Big Bear
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source