Results 101 to 110 of about 9,327,337 (301)
, 1984 Photograph album created by Big Bear supermarkets to celebrate their 50th anniversary. The cover reads, " The Big Bear Family Album: The First 50 Years: 1934-1984 [50 Years: Quality Supermarkets Since 1934]." The first pages of the album give a brief ...
Big Bear
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Big Thicket National Preserve Field Research Station Pamphlet
, 2000 Pamphlet with information on the Field Research Station in Big Thicket National Preserve, including a map and information to reserve the ...
Big Thicket National Preserve
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Journal of Big HistoryBuilding on foundational work in systems theory, thermodynamics, and evolutionary theory, this paper argues that complexity can serve as a conceptual bridge across disciplines. It explores the role of complexity dynamics in Big History through an integrative theoretical framework that spans physical, chemical, geological, biological, social, cognitive,
David J. LePoire +2 more
openaire +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The Star-Galaxy Era in Terms of Big History and Universal Evolution
Journal of Big History, 2019 The present article attempts at combining Big History potential with the po-tential of Evolutionary Studies. It does not only analyze the history of the Cosmos.
Leonid E. Grinin, Anton Grinin
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
1958 illuminated Big Bear billboard
, 1958 Illuminated Big Bear billboard from 1958. The billboard reads, " Big Bear. Always convenient parking! Columbus most modern super markets." In 1934, an innovation in food retailing was introduced in Columbus when Wayne E.
Big Bear
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FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source