Results 101 to 110 of about 205,796 (267)
Wayne E. Brown on horseback at Big Bear Farms
, 1962 Black and white photograph of Big Bear stores President, Wayne E. Brown, at Big Bear Farms in Powell, Ohio. In 1934, an innovation in food retailing was introduced in Columbus when Wayne E. Brown opened the first self-service supermarket in central Ohio.
Big Bear
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Produce at the Lancaster Big Bear location
, 1940 Produce department at the Lancaster, Ohio Big Bear location. Big Bear is responsible for many innovations in the supermarket business. They were the first to introduce motorized counters that were controlled by the cashier.
Big Bear
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
, 2023 Quarterly newsletter of the Big Thicket Association discussing news, events, and other updates related to the work of the group and the Big Thicket ...
Big Thicket Association
core
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Bowman Dairy Company mascot "Bud Bowman" and "Big Bear" photograph
, 1930 Bowman Dairy Company mascot "Bud Bowman" and "Big Bear" standing outside the Buckeye Premium Stamp Redemption Center, Big Bear Store #1, Lane Avenue, Columbus, Ohio. The Lane Avenue store, which opened in 1934, was the first Big Bear store and the first
Big Bear
core
, 2022 Quarterly newsletter of the Big Thicket Association discussing news, events, and other updates related to the work of the group and the Big Thicket ...
Big Thicket Association
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Wayne E. Brown at Toledo Big Bear location
, 1950 Wayne E. Brown at toledo big bear location. In 1934, an innovation in food retailing was introduced in Columbus when Wayne E. Brown opened the first self-service supermarket in central Ohio. The name “Big Bear” was chosen because Brown felt it was catchy
Big Bear
core