Results 101 to 110 of about 2,341,004 (290)

An Exploration of Historical Transitions with Simple Analogies and Empirical Event Rates

open access: yesJournal of Big History, 2019
Various qualitative models have been suggested for major historical social and technological transitions. Many of these transitions still have puzzling aspects such as the early transition from hunter-gatherer to agriculturally-based society which ...
David J. LePoire
doaj   +1 more source

Complexity in Big History [PDF]

open access: yesCliodynamics: The Journal of Quantitative History and Cultural Evolution, 2011
Big history can also be summarized as providing an overview of the rise and demise of complexity in all its forms and manifestations ever since the beginning of the universe. If we want to pursue this approach to big history, we need a theoretical framework that facilitates us to do so.
openaire   +3 more sources

Managing Research Data: Gravitational Waves [PDF]

open access: yes, 2012
The project which led to this report was funded by JISC in 2010–2011 as part of its ‘Managing Research Data’ programme, to examine the way in which Big Science data is managed, and produce any recommendations which may be appropriate. Big science data
Carozzi, T.D., Gray, N., Woan, G.
core  

Fate of Yang-Mills black hole in early Universe

open access: yes, 2013
According to the Big Bang Theory as we go back in time the Universe becomes progressively hotter and denser. This leads us to believe that the early Universe was filled with hot plasma of elementary particles.
Nakonieczny, Łukasz, Rogatko, Marek
core   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

open access: yes
Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana   +8 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

What can we learn from a master plot of energy rate versus mass for a very wide variety of (complex) systems?

open access: yesJournal of Big History
Mass and energy rate (ER) data have been collected for a wide variety of (complex) systems from the biological, cultural, and cosmological realms. They range from the cytochrome oxidase protein (10-22 kg and 6x10-19 W) to the observable universe (1 ...
Martin van Duin
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Was there a Big Bang?

open access: yesJournal of Big History, 2019
The idea that our Universe emerged as a result of the extraordinary power of the Big Bang from singularity (i.e., a state of an infinitely small quantity and infinitely high concentration of matter) is still very popular today.
Leonid Grinin
doaj   +1 more source

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