Results 71 to 80 of about 205,796 (267)

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Mega-History and the 21st century singularity puzzle [PDF]

open access: yesФилософия и космология, 2015
A series of calculations carried out independently by the Australian, Russian and American re- searchers have demonstrated that a crucial global polyfurcation is expected near the middle of the 21st century. This result is drawn by extrapolating into the
Akop P. Nazaretyan
doaj  

O que é a Grande História?

open access: yesJournal of Big History, 2018
A grande história é um novo campo disciplinar acadêmico que estuda o passado em todas as suas possíveis escalas. Sua abordagem é histórica, mas reúne disciplinas da cosmologia à geologia, da biologia evolucionária à história humana.
David Christian
doaj   +1 more source

1958 illuminated Big Bear billboard

open access: yes, 1958
Illuminated Big Bear billboard from 1958. The billboard reads, " Big Bear. Always convenient parking! Columbus most modern super markets." In 1934, an innovation in food retailing was introduced in Columbus when Wayne E.
Big Bear
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

What can we learn from a master plot of energy rate versus mass for a very wide variety of (complex) systems?

open access: yesJournal of Big History
Mass and energy rate (ER) data have been collected for a wide variety of (complex) systems from the biological, cultural, and cosmological realms. They range from the cytochrome oxidase protein (10-22 kg and 6x10-19 W) to the observable universe (1 ...
Martin van Duin
doaj   +1 more source

An Exploration of Historical Transitions with Simple Analogies and Empirical Event Rates

open access: yesJournal of Big History, 2019
Various qualitative models have been suggested for major historical social and technological transitions. Many of these transitions still have puzzling aspects such as the early transition from hunter-gatherer to agriculturally-based society which ...
David J. LePoire
doaj   +1 more source

Cleveland Avenue Big Bear promotion

open access: yes, 1954
3515 Cleveland Ave. Columbus, Ohio. In 1934, an innovation in food retailing was introduced in Columbus when Wayne E. Brown opened the first self-service supermarket in central Ohio.
Big Bear
core  

Man operating a computer at Big Bear stores

open access: yes, 1962
Grocers Beacon, Special Edition on Big Bear. In 1934, an innovation in food retailing was introduced in Columbus when Wayne E. Brown opened the first self-service supermarket in central Ohio.
Big Bear
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

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