Results 61 to 70 of about 205,796 (267)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
The Polyfurcation Century: Does the Evolution on Earth Have a Cosmological Relevance?
Journal of Big History, 2018 Special cross-disciplinary research and respective calculations done independently by scientists from various countries have shown that the 21st century is expected to be crucial for the human history.
Akop P. Nazaretyan
doaj +1 more source
, 1962 Black and white photograph of Big Bear Farms in Powell, Ohio. Big Bear Farms provided a good portion of the meats offered by the self service Big Bear chain stores.
Big Bear
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Journal of Big History, 2018 O objetivo deste artigo é o de estabelecer uma narrativa macrohistórica acerca da emergência da guerra e da ética social como condições simplesiomórficas na linhagem de Homo sapiens. Isso significa que esses dois aspectos comportamentais, que representam
Daniel Barreiros
doaj +1 more source
'Big History', history and citations in nutritional science. [PDF]
J Nutr Sci, 2022 Trayhurn P.
europepmc +1 more source
Zanesville Big Bear canned goods
, 1948 Canned goods at Zanesville Big Bear location, in June of 1948. Big Bear is responsible for many innovations in the supermarket business. They were the first to introduce motorized counters that were controlled by the cashier. Unique store layouts placing
Big Bear
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The Great Matrix of All Beings
Journal of Big History, 2018 Learning “the big ideas of all the big disciplines,” as famed investor Charlie Munger suggests, is not really all that hard. Indeed, he claims it is both fun and profitable. He recommends that we build “a latticework of mental modules.” Science offers a
William Grassie
doaj +1 more source
Zanesville Big Bear store interior
, 1948 Canned goods at Zanesville Big Bear location, in June of 1948. Big Bear is responsible for many innovations in the supermarket business. They were the first to introduce motorized counters that were controlled by the cashier. Unique store layouts placing
Big Bear
core