Results 211 to 220 of about 2,341,004 (290)

Gender-specific associations between personality traits and mental health status of intensive care unit patients' family members. [PDF]

Eur J Med Res
Wang C, Yi S, Tian T, Zhao Z, Wang L, Zhang X, Zeng M, Liu T, Wang L.   +8 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Exceedingly low genetic diversity in snow leopards due to persistently small population size. [PDF]

Proc Natl Acad Sci U S A
Solari KA, Morgan S, Poyarkov AD, Weckworth B, Samelius G, Sharma K, Ostrowski S, Ramakrishnan U, Kubanychbekov Z, Kachel S, Johansson Ö, Lkhagvajav P, Hemmingmoore H, Alexandrov DY, Bayaraa M, Grachev A, Korablev MP, Hernandez-Blanco JA, Munkhtsog B, Rosenbaum B, Rozhnov VV, Madad Rajabi A, Noori H, Suryawanshi KR, Armstrong EE, Petrov DA.   +25 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

A Review of Recent Developments in Artificial Intelligence and Big Data Technologies for Ophthalmology Referrals and Clinical Practice. [PDF]

Med Sci Monit
Paredes AA, Banoub RG, Gill GS, Bains HK, Sibia AS, Sanghvi HA, Gupta SK, Chalam KV.   +7 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

The Small Bowel's Big Secret: A Case of Hidden Adenocarcinoma Unmasked by Capsule Endoscopy. [PDF]

Cureus
Kiran SK, Hussain R, Raza A, Gul H, Maheshwari P.   +4 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source