Results 231 to 240 of about 205,796 (267)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Magnitude of short birth intervals and associated factors among reproductive-age women in sub-Saharan Africa: a multilevel modified Poisson regression analysis of recent DHS data (2021-2024). [PDF]

Contracept Reprod Med
Wondmeneh TG.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Development and validation of an interpretable machine learning model for predicting urinary incontinence at 6 months after robot-assisted radical prostatectomy. [PDF]

J Robot Surg
Yu W, He Y, Ma Y, Zhang J, Wu J, Liang C, Zhang M, Yang C.   +7 more
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Zone 3 Aggressive Retinopathy of Prematurity in a Near-Term Delivered Big Baby With a Birth Weight of 3,200 g. [PDF]

Cureus
Jain KS, Takkar B, Belenje A.
europepmc   +1 more source

Platelet-rich plasma combined with multimodal therapy for diabetic foot ulcer with tophi: a case report. [PDF]

Front Clin Diabetes Healthc
Duan X, Sun X, Liu Y, Chen M, Dong L.
europepmc   +1 more source

Current developments of Psychological Research and the use of AI. [PDF]

Psychol Res
Strobach T, Pazhoohi F.
europepmc   +1 more source