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Recent progress in asymmetric Biginelli reaction
Molecular Diversity, 2013The Biginelli reaction, which involves the interaction of ethyl acetoacetate, urea, and an appropriate aryl aldehyde, was first discovered by Pietro Biginelli about 120 years ago. The Biginelli products (3,4-dihydropyrimidin-2(1H)-ones) are interesting materials due to their significant pharmacological and structural profiles.
Majid M, Heravi +2 more
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Biginelli reaction: an overview
Tetrahedron Letters, 2016Abstract Biginelli reaction involves acid-catalyzed one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) using easily-accessible starting materials, namely, aldehyde, active methylene compound and (thio)urea. DHPMs have stimulated resurgence of interest in the past two decades due to their wide ranging pharmacological activities and presence ...
Honnappa Nagarajaiah +2 more
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Tandem Hydroformylation-Biginelli Reaction
Synlett, 2013The combination of a tandem process with a multicomponent reaction is a new approach to high atom-economic synthesis. A tandem hydroformylation–Biginelli reaction sequence has been developed leading to a variety of functionalized 4-alkyl-substituted 3,4-dihydropyrimidin-2(1H)-ones.
Fuchs, Daniela +4 more
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ChemInform Abstract: Biginelli Reaction
ChemInform, 2008AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Anil Saini +2 more
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Biginelli Reaction: Polymer Supported Catalytic Approaches
ACS Combinatorial Science, 2019The Biginelli product, dihydropyrimidinone (DHPM) core, and its derivatives are of immense biological importance. There are several methods reported as modifications to the original Biginelli reaction. Among them, many involve the use of different catalysts.
Rajendra V. Patil +4 more
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2‐Phenacylbenzothiazole in the Biginelli Reaction.
ChemInform, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
I. B. Dzvinchuk +2 more
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An Inexpensive Protocol for Biginelli Reaction
Synthetic Communications, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
A. Manjula +2 more
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New catalysts of Biginelli reaction
Russian Journal of Organic Chemistry, 2007A synthesis was developed of new imidazole derivatives catalyzing three-component condensation of ethyl acetoacetate, aromatic aldehydes, and urea(or thiourea) by Biginelli reaction.
F. Makaev +5 more
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ChemInform, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
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Aminoheterocycles as synthons for combinatorial Biginelli reactions
Molecular Diversity, 2010Chlorotrimethylsilane (TMSCl) has been utilized as an efficient promoter and water scavenger in the synthesis of diverse dihydropyrimidines via Biginelli type MCR-heterocyclization using aminoheterocycles. High yields and a simple workup of target compounds enable the facile generation of combinatorial libraries comprising more than 2,000 compounds of ...
Sergey V, Ryabukhin +4 more
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