Results 181 to 190 of about 6,057 (253)
Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood +7 more
wiley +1 more source
Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance
Medicinal Research Reviews, EarlyView.ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi +4 more
wiley +1 more source
Leveraging Public Transit for Robotic Deliveries: A Column Generation Approach
Naval Research Logistics (NRL), EarlyView.ABSTRACT Autonomous mobile robots (AMRs) are small, electric, wheeled vehicles that operate at pedestrian speeds. In the last‐mile delivery service considered in this study, a fleet of AMRs is deployed across multiple recharging depots within a service area, from which they depart to perform point‐to‐point deliveries. We consider an operational setting
Yishay Shapira, Mor Kaspi
wiley +1 more source
Allocation of Indivisible Items With a Common Preference Graph: Minimizing Total Dissatisfaction
Networks, EarlyView.ABSTRACT Allocating indivisible items among a set of agents is a frequently studied discrete optimization problem. In the setting considered in this work, the agents' preferences over the items are assumed to be identical. We consider a very recent measure for the overall quality of an allocation which does not rely on numerical valuations of the items.
Nina Chiarelli +6 more
wiley +1 more source
Simultaneous Network Design With Restricted Link Usage
Networks, EarlyView.ABSTRACT Given a digraph with two terminal vertices s$$ s $$ and t$$ t $$ as well as a conservative cost function and several not necessarily disjoint color classes on its arc set, our goal is to find a minimum‐cost subset of the arcs such that its intersection with each color class contains an s$$ s $$‐t$$ t $$ dipath.
Naonori Kakimura +3 more
wiley +1 more source
Public Administration and Development, EarlyView.ABSTRACT This article examines how a local environmental NGO in southern China transformed Guantouling Hill, once a prominent poaching hotspot along the East Asian–Australasian Flyway, into a recognised model of community‐based biodiversity conservation.
Zheng Lin, Miao Chen
wiley +1 more source
People and Nature, EarlyView.Abstract The future of land use in the UK uplands is highly debated, with growing interest in increasing tree cover and other land use changes, alongside a desire to maintain traditional land use patterns and practices. Treescape expansion is likely to result in synergies and trade‐offs between different outcomes, so integrating stakeholder preferences
Melissa Minter +6 more
wiley +1 more source
People and Nature, EarlyView.Abstract Forests and woodlands are important for biodiversity, climate change mitigation and the provision of services including recreation, timber and non‐timber forest products. Land use policies currently aim to increase forest cover while also maximising the benefits of forests for people and improving community engagement with the process of ...
Sarah Greenwood +6 more
wiley +1 more source