Results 41 to 50 of about 5,860 (253)

Beyond Simple Mimicry: Next‐Generation Geometric Architectures and Future Paradigms in Small‐Molecule and Macrocyclic Peptidomimetics

open access: yesAngewandte Chemie, EarlyView.
Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee   +5 more
wiley   +2 more sources

Unlocking Trends: Socio-Demographic Insights into Bike Sharing from the 2017 National Household Travel Survey

open access: yesUrban Science
The implementation of bike-sharing systems represents a novel strategy aimed at enhancing urban mobility by offering shared bicycle services to improve accessibility and user convenience.
Chia-Yuan Yu
doaj   +1 more source

Charting the Future of Stereoselective Carbohydrate Synthesis: The Essential Role of Cross‐Disciplinary Innovation

open access: yesAdvanced Science, EarlyView.
Cross‐disciplinary endeavors are blossoming across the broad chemical sciences. This perspective provides a glimpse into the rewarding interdisciplinary journey taken by the Charles Loh research group in pioneering the σ‐hole based catalytic glycosylation strategy.
Charles C. J. Loh
wiley   +1 more source

A Systematic Review of the Coopetition Relationship between Bike-Sharing and Public Transit

open access: yesJournal of Advanced Transportation
The sharing economy, mobile Internet, and smartphones have been widely utilized in recent years to promote the development of bike-sharing services. Bike-sharing serves as a first/last mile travel mode to connect to public transit, which improves trip ...
Jianhong Ye, Jiahao Bai, WenYang Hao
doaj   +1 more source

Factors influencing bike share intentions of users in Indian cities: a structural equation modelling approach

open access: yesUrban, Planning and Transport Research, 2023
Public bike sharing is an increasingly popular mode of transportation in India, and understanding the factors influencing the intention to use bike share is crucial.
Pavan Kumar Machavarapu   +2 more
doaj   +1 more source

TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers

open access: yesAdvanced Science, EarlyView.
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei   +10 more
wiley   +1 more source

Flavin Catalysts in Organic Synthesis

open access: yesAngewandte Chemie, EarlyView.
Flavins and their congeners are potent catalysts for organic synthesis inspired by enzymatic transformations. In addition to catalysis in the flavin ground state via covalent intermediates, the excited singlet and triplet states unlock applications including photooxidation, photoreduction, and energy transfer via sensitization.
Jan Freudenberg, Golo Storch
wiley   +2 more sources

Bike share responses to COVID-19

open access: yesTransportation Research Interdisciplinary Perspectives, 2021
Bike sharing can leverage its physical distancing advantages for responding to the COVID-19 pandemic, but system management and communication are essential to support healthy transportation. This study addresses the need to understand the range of bike share systems' responses to the pandemic by reviewing bike share system cases in the United States ...
Jeffrey Jobe, Greg P. Griffin
openaire   +3 more sources

Safety of Sodium‐Ion Batteries: Evaluation and Perspective from Component Materials to Cells, Modules, and Packs

open access: yesAdvanced Energy Materials, EarlyView.
This review provides a bottom‐up evaluation of sodium‐ion battery safety, linking material degradation mechanisms, cell engineering parameters, and module/pack assembly. It emphasizes that understanding intrinsic material stability and establishing coordinated engineering control across hierarchical levels are vital for preventing degradation coupling ...
Won‐Gwang Lim   +5 more
wiley   +1 more source

Borylcyclopropanes: Synthetic Strategies and Applications

open access: yesAngewandte Chemie, EarlyView.
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley   +2 more sources

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