Results 51 to 60 of about 6,057 (253)
Advanced Science, EarlyView.An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei +10 more
wiley +1 more source
Advanced Science, EarlyView.Two‐photon calcium imaging in behaving 5xFAD mice reveals early CA1 coding deficits before behavioral decline. Task‐related place cell activity and splitter cell trajectory coding are impaired, with reduced retrospective dominance and greater prospective weighting.
Yimei Li +8 more
wiley +1 more source
IEEE AccessDemand uncertainty and variations in user rental-return behavior can lead to an uneven spatial distribution of bicycles, which forces bike-sharing operators to rebalance the bike-sharing system by relocating bicycles from overstocked to understocked ...
Lijun Yu +3 more
doaj +1 more source
Advanced Science, EarlyView.Non‐canonical amino acids (ncAAs) enhance peptide therapeutics but remain difficult to model computationally. SinCAA, a similarity‐enhanced pretraining framework, jointly optimizes contrastive learning guided by a novel conformational similarity metric with masked node reconstruction, capturing both functional relationships and chemical identity of ...
Chencheng Xu +8 more
wiley +1 more source
Bike-sharing as a possibility to support Vision Zero
MATEC Web of Conferences, 2018 Cyclists as unprotected road users are one of the most vulnerable groups of travelers. In order to improve their safety, various activities are carried out.
Turoń Katarzyna, Sierpiński Grzegorz
doaj +1 more source
Performance of LoRa for Bike-Sharing Systems [PDF]
2019 AEIT International Conference of Electrical and Electronic Technologies for Automotive (AEIT AUTOMOTIVE), 2019 Today bike sharing systems are becoming popular in many cities as short-distance transit vehicles. More than 18 million bicycles are available worldwide for public use and one of the main problems that afflicts such sharing systems is the loss of bikes, which can be stolen or simply left in unknown locations.
Daniele Croce +5 more
openaire +2 more sources
Advanced Science, EarlyView.A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung +15 more
wiley +1 more source
Angewandte Chemie, EarlyView.Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma +5 more
wiley +2 more sources
Impacts of Smart Configuration in Pedelec-Sharing: Evidence from a Panel Survey in Madrid
Journal of Advanced Transportation, 2017 Despite the recently increasing research interest, this is one of the first studies employing a panel sample of users and nonusers to understand the bike-sharing phenomenon (N=205). On the basis of a novel surveying technique, a case study on the clients
András Munkácsy, Andrés Monzón
doaj +1 more source
Advanced Science, EarlyView.Extrusion‐based 3D printing of silicones and discrete electronic components are combined to create cortical implants for rodents that integrate thermal neuromodulation and electrical recording. Linked to an autonomous auxiliary driver unit, the system enables rapid, stable and localized hypothermia alongside ECoG recording.
Spencer Ryan Moore +6 more
wiley +1 more source