Results 201 to 210 of about 18,049 (263)
ESC Heart Failure, Volume 12, Issue 2, Page 1326-1335, April 2025.Abstract Aims Amyloid cardiomyopathy is caused by the deposition of light chain (AL) or transthyretin amyloid (ATTR) fibrils, that leads to a restrictive cardiomyopathy, often resulting in heart failure (HF) with preserved or reduced ejection fraction.
Robin Willixhofer +25 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira +12 more
wiley +1 more source
Gold(I)‐Mediated Reactivity of Allenes With Mesoionic Nucleophiles: A Computational Exploration
European Journal of Organic Chemistry, EarlyView.The regioselective gold(I)‐mediated reactivity of allenes with mesoionic nucleophiles has been evaluated through computational analysis of the mechanisms involved. Instead of typical (3 + 2) pathways, sydnones and münchnones favour the formal (3 + 3) cyclizations affording substituted dihydropyridines.
Eduardo Garcia‐Padilla, Feliu Maseras
wiley +1 more source
European Journal of Organic Chemistry, EarlyView.Chiral tri‐ and pentahydroxy spirocyclopentane‐indolizidines were synthesized using lithium diisopropylamide “LDA” promoted diallylation and tetrahydrofuran “THF” ring‐opening in a one‐pot procedure as a key step. The sequence leading to the targeted hydroxy‐spiroindolizidines was achieved by cis‐dihydroxylation followed by reduction of the enamine and
Paula Fraňová +6 more
wiley +1 more source
European Journal of Organic Chemistry, EarlyView.The regio‐ and stereoselective synthesis of ring‐fused α‐hydroxy‐2‐cyclopentenones is achieved by a one‐pot gold(I)‐catalyzed Rautenstrauch rearrangement/nitrosocarbonyl hetero‐Diels–Alder reaction/ring opening sequence carried out on suitable propargyl esters followed by selective NO bond cleavage.
Dina Scarpi +3 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective A strong bidirectional relationship exists between epilepsy and sleep, with seizures often occurring more frequently in sleep and, in turn, sleep being disrupted by seizures. However, the mechanistic basis of seizure–sleep interactions is poorly understood.
Nicholas R. Rensing +4 more
wiley +1 more source
Creativity and its link to epilepsy
Epilepsia Open, EarlyView.Abstract Creative thinking represents one of our highest‐order cognitive processes, involving multiple cortical structures and an intricate interplay between several cortical and subcortical networks. It results in novel ideas that translate to useful products or concepts. The evolutionary purpose of creativity is therefore apparent, as it advances our
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source
Detection of focal impaired awareness seizures using a biometric shirt
Epilepsia Open, EarlyView.Abstract Objective In recent years, seizure detection using wearable technology has gained significant attention in research. Most studies, however, have focused on detecting generalized or focal to bilateral tonic–clonic seizures. This study evaluates the feasibility of using a biometric shirt to detect focal impaired awareness seizures (FIAS) by ...
Jérôme St‐Jean +6 more
wiley +1 more source
Energy Science &Engineering, EarlyView.This study develops and evaluates a solar PV‐fed electric bicycle system optimized for university campuses in Pakistan. The techno‐economic analysis demonstrates significant fuel savings, emission reductions, and sustainability benefits, promoting a cost‐effective, eco‐friendly, and renewable transportation alternative amid rising global fuel and ...
Muhammad Abdullah Khan +4 more
wiley +1 more source