Results 1 to 10 of about 50,331 (120)

Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist

open access: yesJournal for ImmunoTherapy of Cancer, 2021
Background In contrast to immune checkpoint inhibitors, the use of antibodies as agonists of immune costimulatory receptors as cancer therapeutics has largely failed.
Sailaja Battula   +18 more
doaj   +1 more source

Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2

open access: yesNature Communications, 2023
COVID-19 has stimulated the rapid development of new antibody and small molecule therapeutics to inhibit SARS-CoV-2 infection. Here we describe a third antiviral modality that combines the drug-like advantages of both.
Katherine U. Gaynor   +31 more
doaj   +1 more source

DirectMX – One-Step Reconstitution of Membrane Proteins From Crude Cell Membranes Into Salipro Nanoparticles

open access: yesFrontiers in Bioengineering and Biotechnology, 2020
Integral membrane proteins (IMPs) are central to many physiological processes and represent ∼60% of current drug targets. An intricate interplay with the lipid molecules in the cell membrane is known to influence the stability, structure and function of ...
Pilar Lloris-Garcerá   +5 more
doaj   +1 more source

How Many Cars in the City Are Too Many? Towards Finding the Optimal Modal Split for a Multi-Modal Urban Road Network

open access: yesFrontiers in Future Transportation, 2021
Interactions among different modes or vehicle classes in urban road networks affect the network performance in different and complex ways. Thus, an answer to the question of “how many cars are too many for a city?” is not trivial.
Allister Loder   +9 more
doaj   +1 more source

Dangerous Overtaking of Cyclists in Montréal

open access: yesSafety, 2022
It is largely consented that the bicycle is a sustainable mobility alternative in the city. Despite its many benefits, cycling comprises risks of injury or death.
Andres Henao, Philippe Apparicio
doaj   +1 more source

Research on hot extrusion forming of 7075 aluminum alloy wheel profile

open access: yesMetalurgija, 2023
Design the wheel mold according to the cross-sectional view of the lightweight aluminum alloy wheel profile, determine the length of its working belt and use HyperXtrude software to simulate it, verify the rationality of the working belt design, analyze ...
S. K. Shi   +5 more
doaj  

Selected issues of designing cycling infrastructure in the aspect of road traffic safety

open access: yesRoads and Bridges, 2021
Increasing mobility results in growing overcrowding of roads and streets. Attempts to improve travel conditions through an increase in road capacity usually only worsen the situation.
Andrzej Brzeziński   +1 more
doaj   +1 more source

Features of bicycle abreast riding and its application in bicycle facility operating evaluation and design optimization

open access: yesAdvances in Mechanical Engineering, 2017
This article aims to measure bicycle facility operating state based on the survey and analysis of bicycles’ abreast riding. We conducted a detailed bicycle operating investigation consisting of four exclusive bicycle paths in Nanjing, China, and ...
Xingchen Yan   +4 more
doaj   +1 more source

Modelling the Obstacles to using Bicycle Sharing Systems in the Tehran Metropolis: A Structural Analysis

open access: yesQuaestiones Geographicae, 2022
The main objective of the current research is to identify and prioritise the obstacles to using bicycle sharing systems (BSSs) in the Tehran metropolis. The methodology of this research is analytical-descriptive and it aims to achieve applied goals.
Akbari Majid   +4 more
doaj   +1 more source

The Effect of Environmental Differences on EEG and Mood State in Bicycle Exercise [PDF]

open access: yesThe Asian Journal of Kinesiology
OBJECTIVES The purpose of this study is to compare and analyze the effects of environmental differences on EEG and mood states in bicycle exercise. METHODS A total of 60 participants took part, with 20 participants each in indoor, outdoor, and virtual ...
Jonghwa Lee, Youngho Kim
doaj   +1 more source

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