Results 11 to 20 of about 92,101 (311)
J Pept SciABSTRACT Bicyclic peptides are emerging as next generation therapeutics by combining the affinity and specificity of antibodies with the synthetic convenience of small molecules. Phage‐encoded libraries of bicyclic peptides enable the discovery of high‐affinity molecules against virtually any protein target.
Voss S +8 more
europepmc +3 more sources
Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist
Journal for ImmunoTherapy of Cancer, 2021 Background In contrast to immune checkpoint inhibitors, the use of antibodies as agonists of immune costimulatory receptors as cancer therapeutics has largely failed.
Sailaja Battula +18 more
doaj +1 more source
Nature Communications, 2023 COVID-19 has stimulated the rapid development of new antibody and small molecule therapeutics to inhibit SARS-CoV-2 infection. Here we describe a third antiviral modality that combines the drug-like advantages of both.
Katherine U. Gaynor +31 more
doaj +1 more source
TeMA: Journal of Land Use, Mobility and Environment, 2021 Cycling as an attractive mode of transport is a challenge, especially in developing countries like Pakistan. Previous research on cycling in developing countries is insufficient to answer that how people can be encouraged to bike in different regions and
Izza Anwer +3 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2020 Integral membrane proteins (IMPs) are central to many physiological processes and represent ∼60% of current drug targets. An intricate interplay with the lipid molecules in the cell membrane is known to influence the stability, structure and function of ...
Pilar Lloris-Garcerá +5 more
doaj +1 more source
Frontiers in Future Transportation, 2021 Interactions among different modes or vehicle classes in urban road networks affect the network performance in different and complex ways. Thus, an answer to the question of “how many cars are too many for a city?” is not trivial.
Allister Loder +9 more
doaj +1 more source
Dangerous Overtaking of Cyclists in Montréal
Safety, 2022 It is largely consented that the bicycle is a sustainable mobility alternative in the city. Despite its many benefits, cycling comprises risks of injury or death.
Andres Henao, Philippe Apparicio
doaj +1 more source
“Bicycles and Tricycles” [PDF]
Nature, 1897 IN reading Mr. Boys' most interesting review of Mr. Sharp's book on “Bicycles and Tricyles” (NATURE, July 8), a few points occur to me as requiring further notice.
openaire +1 more source
Research on hot extrusion forming of 7075 aluminum alloy wheel profile
Metalurgija, 2023 Design the wheel mold according to the cross-sectional view of the lightweight aluminum alloy wheel profile, determine the length of its working belt and use HyperXtrude software to simulate it, verify the rationality of the working belt design, analyze ...
S. K. Shi +5 more
doaj