Results 221 to 230 of about 3,593,458 (250)

Efficacy and related factors of levonorgestrel‐releasing intrauterine system combined with metformin in fertility‐preserving treatment for atypical endometrial hyperplasia and early endometrial cancer: A retrospective cohort study

International Journal of Gynecology &Obstetrics, Volume 175, Issue 1, Page 396-407, October 2026.
Abstract Objective To compare the efficacy of the levonorgestrel‐releasing intrauterine system combined with metformin versus oral progestin combined with metformin in fertility‐preserving treatment for patients with atypical endometrial hyperplasia and early endometrial cancer, and to analyze related factors affecting efficacy.
Pengpeng Gu, Jialu Gao, Yuxin Li, Mei Huang, Xiaoshuang Wang, Xin Zhao   +5 more
wiley   +1 more source

Hormone therapy (HT) in women with premature ovarian insufficiency or early menopause: Time to think of a new paradigm for healthy aging. A joint FIGO and IMS position paper

International Journal of Gynecology &Obstetrics, Volume 175, Issue 1, Page 26-47, October 2026.
Abstract Premature ovarian insufficiency (POI) and early menopause (EM) affect millions of women worldwide. Compared with normal menopause, they confer a longer duration of estrogen deficiency and are associated not only with a shorter lifespan, but with a reduced healthspan, owing to an increased risk of cardiovascular, skeletal, cognitive and ...
Chiara Benedetto, Suvarna S. Khadilkar, Rossella E. Nappi, Andrea R. Genazzani, Federica Frezet, Laura Cucinella, Hema Divakar, Panagiotis Anagnostis, Nick Panay   +8 more
wiley   +1 more source

Breast Cancer‐Derived AZU1 Educates Neutrophils to Promote Tumor Progression and Metastasis Through PAD4‐Dependent Extracellular Trap Formation

Molecular Carcinogenesis, Volume 65, Issue 10, Page 1281-1296, October 2026.
ABSTRACT Neutrophil extracellular traps (NETs) play crucial roles in cancer progression, but their regulatory mechanisms in breast cancer remain poorly understood. We developed a NETs‐related prognostic risk model using TCGA breast cancer data and identified key biomarkers through bioinformatics analysis.
Zhen Huang, Zhe Wu, Guiyue Zhu, Fangyu Qiu, Lihui Li, Yujie Xie, Chunyu Wei, Yinhua Pan, Quanqing Zou, Yuntian Tang   +9 more
wiley   +1 more source

Integrative Multiomics Profiling Reveals Immune Determinants of Response to Disitamab Vedotin Plus Penpulimab in HER2‐Low Breast Cancer

MedComm, Volume 7, Issue 10, October 2026.
This prospective single‐arm study evaluated neoadjuvant disitamab vedotin plus penpulimab in 20 patients with Stage II–III HER2‐low breast cancer. The regimen showed preliminary activity (pCR 20.0% intention‐to‐treat, 25.0% evaluable; ORR 56.3%) with manageable toxicity.
Xiaoxiao Liu, Yuting Song, Lei Liu, Aaron Qi Zhang, Xin Xie, Bing Wei, Ping He, Chunying Zhuang, Juanjuan Li, Xi Yan, Tinglun Tian, Xiaorong Zhong, Jie Chen, Yan Cheng, Dan Zheng, Shibao Li, Hao Wang, Ting Luo   +17 more
wiley   +1 more source

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

Blind Estimation Versus Direct Measurement of the Arterial Input Function in Dynamic Contrast‐Enhanced MRI of the Breast

Magnetic Resonance in Medicine, Volume 96, Issue 4, Page 1947-1955, October 2026.
PurposeAccurate arterial input functions (AIFs) are essential for quantitative dynamic contrast‐enhanced (DCE) MRI, yet direct measurement is challenging and population‐averaged AIFs neglect patient‐specific variability. Blind deconvolution provides an alternative by estimating patient‐specific AIFs directly from tissue data, up to a scale factor. This
Jake L. Cray, Jiří Vitouš, Radovan Jiřík, Sofya Titarenko, David L. Buckley   +4 more
wiley   +1 more source

Myasthenia Gravis and Thymoma

Muscle &Nerve, Volume 74, Issue 4, Page 1156-1173, October 2026.
ABSTRACT Thymoma is the most common tumor of the anterior mediastinum. Approximately 20%–30% of patients with a thymoma develop myasthenia gravis (MG), and an additional one third may possess positive acetylcholine receptor (AChR) antibodies without MG.
Benjamin Claytor, Lukas Delasos, Daniel P. Raymond, Erik Seroogy, Jason Lempel, Yuebing Li   +5 more
wiley   +1 more source

Hyperpolarized MRI in Oncology—A Review of Clinical Studies and Evaluation of Preclinical Liver Studies

NMR in Biomedicine, Volume 39, Issue 10, October 2026.
Hyperpolarized MRI is a promising clinical imaging modality in oncology, offering at least nine imaging contrasts obtainable with hyperpolarized [1‐13C]pyruvate as the injected agent, depending on the tissue and condition under investigation. Preclinical studies suggest that hyperpolarized MRI is warranted for detecting hepatocellular carcinoma within ...
Naama Lev‐Cohain, Jacob Sosna, Rachel Katz‐Brull   +2 more
wiley   +1 more source

Abstracts of 14th International Symposium on Hodgkin Lymphoma

HemaSphere, Volume 10, Issue S2, October 2026.
wiley   +1 more source