Results 81 to 90 of about 277,238 (258)

Surgical intervention for binocular blindness in pituitary apoplexy

Interdisciplinary Neurosurgery, 2019
Purpose: Bilateral blindness in patients with pituitary apoplexy is rare and infrequently studied. Visual outcomes after surgical decompression are unpredictable and predictors of favourable outcome not well defined.
Darlene E. Lubbe, MBChB, FCORL(SA), Ncedile Mankahla, MBChB, FC Neurosurg(SA), MMed(UCT), Henri Carrara, Patrick Semple, FCS(Neuro)(SA), MMed (UCT), PhD   +3 more
doaj   +1 more source

Congenital Bilateral Ectropion in Collodion Infants: A Case Series

Cureus
Collodion baby is a rare congenital condition marked by a parchment-like membrane covering the body, often leading to complications such as bilateral ectropion. This condition poses risks of exposure keratopathy and other ocular issues. We present a case series of five infants with congenital bilateral ectropion associated with collodion babies, all ...
Karn, Manish K, Kusumesh, Rakhi, Bhaskar, Gyan, Adhikari, Ashmita   +3 more
openaire   +2 more sources

Familial hypercholesterolemia with bilateral cholesterol granuloma

International Journal of Surgery Case Reports, 2019
Abstract Introduction Cholesterol granuloma is a benign mass that commonly involves the petrous apex but rarely affects other structures, such as the mastoid cavity. It is diagnosed histologically by the presence of giant cells, and Its management is individualized based on some factors such as
Albakheet, Nouf, Al-shawi, Yazeed, Bafaqeeh, Mohammed, Fatani, Hanadi, Orz, Yasser, Shami, Ibrahim   +5 more
openaire   +2 more sources

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Bilateral orchidopexy for intermittent testicular torsion

BJUI Compass
Objectives To assess the effect of bilateral orchidopexy in preventing future torsion and testicular loss in patients with intermittent testicular torsion. Secondarily, this study aims to assess the rate of pain improvement following orchidopexy. Methods
Paul K. Hegarty, Mona Kalantar, Penelope A. Hegarty, Helen Zafirakis, Jack E. Monahan   +4 more
doaj   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

A method of change of force sense for series connection type master slave actuator (To change of force sense without changing mechanical component)

Nihon Kikai Gakkai ronbunshu, 2016
In recent years, surgical robots have come into wider use. These robots do not yet provide a force sense to the surgeon, but such force sense will be necessary on the next generation of surgical robots.
Kunihiko TACHIBANA, Yoshio INOUE, Kazumasa ORIHASHI   +2 more
doaj   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Poster 201. Tumbling Athletes Sustain Highest Rate of Bilateral Elbow Osteochondritis Dissecans Lesions and May Benefit From Screening

Orthopaedic Journal of Sports Medicine
Objective: Osteochondritis dissecans (OCD) lesions frequently present at the capitellum of the elbow, particularly among athletes who participate in overhead sports or impact load through their upper extremity. Bilateral elbow OCD lesions are less common
John Lawrence MD, PhD, Brendon C. Mitchell MD, Kevin M. Landrum, Gavin Rallis, Stone R. Streeter, Monika Thothadri, Casey C. Kuka, Rishika Pasula, Akbar Syed MD, Joseph L. Yellin MD, Apurva S. Shah, Theodore J. Ganley MD   +11 more
doaj   +1 more source