Results 91 to 100 of about 298,331 (266)

The Metabolic Pathway of Bile Secretion Is Vulnerable to Salmonella enterica Exposure in Porcine Intestinal Epithelial Cells

Animals
Pigs can be colonized with Salmonella enterica and become established carriers. However, the mechanisms of the host’s response to Salmonella enterica infection are largely unclear.
Jiajia Cai, Xiaolei Chen, Chao Xu, Xiaoyang Zhu, Haifei Wang, Shenglong Wu, Demin Cai, Hairui Fan   +7 more
doaj   +1 more source

Diabetes Mellitus Facilitates Gallstone Formation Through CXCR2‐NETs–Mediated Liver‐Bile Barrier Damage

Advanced Science, EarlyView.
Diabetes is an independent risk factor for gallstones. It upregulates CXCR2 expression in hepatic neutrophils, stimulating the formation of NETs that disrupt hepatocellular tight junctions and the liver‐bile barrier. NETs enter bile to accelerate gallstone development, while sarcosine inhibits CXCR2 and NETs production, effectively reducing diabetes ...
Chao Shi, Shuo Feng, Tianming Liu, Ziang Meng, Yi Zheng, Zhenghao Huang, Tong Wang, Bojian Zhang, Dongbo Xue, Biao Ma, Xianzhi Meng   +10 more
wiley   +1 more source

Bile Acids

Journal of Biological Chemistry, 1971
null Mei Mei Mui, William H. Elliott
openaire   +1 more source

Multimodal Cross‐Attentive Graph‐Based Framework for Predicting In Vivo Endocrine Disruptors

Advanced Science, EarlyView.
A multimodal cross‐attentive graph neural network integrates molecular graphs with androgen and estrogen adverse outcome pathway (AOP)–anchored in vitro assay signals to predict in vivo endocrine disruption. By fusing information on Tier‐1 AOP logits with chemical structures, the framework achieves high accuracy and provides assay‐traceable ...
Eder Soares de Almeida Santos, Gustavo Felizardo Santos Sandes, Artur Christian Garcia da Silva, Holli‐Joi Martin, Eugene N. Muratov, Rodolpho de Campos Braga, Bruno Junior Neves   +6 more
wiley   +1 more source

Profiling bile acid composition in bile from mice of different ages and sexes

Frontiers in Physiology
IntroductionBile BA profiling is important for understanding the pathogenetic mechanisms underlying gallbladder and gastrointestinal diseases. Until now, bile BAs have been explored mainly in adult male mice.
Jiajian Liu, Qing Zhao, Chun Qu, Kun Ge, Yang Li, Wei Jia, Aihua Zhao   +6 more
doaj   +1 more source

BILE PERITONITIS AND BILE ASCITES

Annals of Surgery, 1929
I S, Ravdin, M E, Morrison, C M, Smyth
openaire   +3 more sources

A Metal‐Free Carbon Monoxide Prodrug Suppresses Metastasis of Pancreatic and Breast Cancer

Advanced Science, EarlyView.
A metal‐free carbon monoxide (CO) prodrug, CO‐116, delivers controlled systemic CO without inhalation. CO suppresses the HRG1–heme axis, reducing intracellular heme availability. Attenuation of this pathway inhibits metastatic progression in pancreatic and triple‐negative breast cancer models.
Tiantian Zhang, Xiang Chen, Xiaoxiao Yang, Muskan Gori, Rohit Kumar Varshnaya, Dongning Liu, Cheryl Zhang, Michelle Yi Qin Chen, Zhengming Chen, George Zhang, Erika Patel, Qiyue Mao, Tan A. Ince, Chalet Tan, Binghe Wang, Yi‐Chieh Nancy Du   +15 more
wiley   +1 more source

Moderate increase in dietary fat induces alterations of microbiota and metabolome along the digestive tract prior to systemic metabolic changes: insights from a pig model

Gut Microbes
The small intestine is a key site for nutrient sensing and host–microbiota interactions, yet how it functionally adapts to dietary changes remains poorly understood.
Axel Ranson, Marta Vazquez Gomez, Rohia Alili, Julia Duraffourd, Oriane Vitalis, Paul Taillandier, Clémentine Rebière, Fatiha Merabtene, Eugeni Belda, Daniel Crespo-Piazuelo, Antonio Gonzalez-Bulnes, Geneviève Marcelin, Adil Mardinoglu, Karim Chikh, Tiphaine Le Roy, Karine Clément   +15 more
doaj   +1 more source

Dual‐Key Genetic Circuit Enables Stable and Self‐Regulated Engineered Bacteria for the Treatment of Ulcerative Colitis

Advanced Science, EarlyView.
A self‐regulated Escherichia coli Nissle 1917 strain equipped with a dual‐key genetic circuit achieved antibiotic‐free stability and programmable lysis for therapeutic protein delivery. By co‐expressing an IL‐2 mutant and Amuc_1100, the engineered bacteria restored immune balance and epithelial integrity, providing a safe and precise approach for ...
Shuaijie Ding, Biao Yang, Xinyu Li, Yi Wang, Chunyu Huang, Wenfei Dong, Wei Xie   +6 more
wiley   +1 more source

Evaluation of microbiological cultures in patients with acute cholecystitis

Frontiers in Surgery
Background and aimsAcute cholecystitis (AC) requires emergency care. Besides surgical interventions, adequate empirical antibiotic therapy is indispensable. We aimed to analyze bile samples obtained during surgical interventions for AC.
Dániel Váczi, Mária Matuz, Ria Benkő, Ria Benkő, Illés Tóth, Emil Terhes, Edit Hajdú, Erika Papfalvi, András Nagy, György Lázár, Szabolcs Ábrahám   +10 more
doaj   +1 more source