Results 311 to 320 of about 5,534,791 (400)

STEROIDS DERIVED FROM BILE ACIDS

, 1948
Vernon R. Mattox, Richard B. Turner, Bernard F. McKenzie, Lewis Engel, Edward C. Kendall   +4 more
openalex   +1 more source

Disrupting bile acid metabolism by suppressing Fxr causes hepatocellular carcinoma induced by YAP activation. [PDF]

Nat Commun
Liu Y, Zhu J, Jin Y, Sun Z, Wu X, Zhou H, Yang Y.   +6 more
europepmc   +1 more source

Optimization of Steroid Photochemistry and Its Application in the Synthesis of 5,6‐Dihydro‐Ophiopogonol A

Chemistry – A European Journal, EarlyView.
Steroid photoreactivity was a major topic in the last century. This study revisits it by exploring the photochemistry of Δ1‐keto‐steroids, offering an efficient method to modify the classic steroid 6/6/6/5 ring system. This approach enables the transformation of accessible steroids into rare ones, demonstrated by synthesizing 5,6‐dihydro‐ophiopogonol A
Chiara Maioli, Gianluigi Lauro, Anna Sategna, Diego Caprioglio, Hawraz Ibrahim M. Amin, Maurizio D'Auria, Daniela Imperio, Giuseppe Bifulco, Alberto Minassi   +8 more
wiley   +1 more source

THE ACID STRENGTH OF BILE ACIDS

, 1941
W. D. Kumler, I. F. Halverstadt
openalex   +1 more source

Interaction of gut microbiota with bile acid metabolism and its influence on disease states

Applied Microbiology and Biotechnology, 2016
C. Staley, Alexa R. Weingarden, A. Khoruts, M. Sadowsky   +3 more
semanticscholar   +1 more source

Corrin Ring Modification in Peptide Drug Development – a Brief History of “Corrination”

ChemMedChem, EarlyView.
This review highlights the applications of vitamin B12 conjugation (“corrination”) to peptides in the field of peptide‐based therapeutics, focusing on improved physio‐chemical properties, targeted/localized drug delivery, and enhanced oral bioavailability.
Nancy Cham, Robert P. Doyle
wiley   +1 more source

Mirabegron induces selective changes in the faecal microbiota of HFHFr rats without altering bile acid composition. [PDF]

Front Pharmacol
Bentanachs R, Miró L, Ramírez-Carrasco P, Sánchez RM, Bernabeu M, Amat C, Alegret M, Pérez-Bosque A, Roglans N, Laguna JC.   +9 more
europepmc   +1 more source

Tumor-resident Malassezia can promote hepatocellular carcinoma development by downregulating bile acid synthesis and modulating tumor microenvironment. [PDF]

Sci Rep
Shen W, Li Z, Wang L, Liu Q, Zhang R, Yao Y, Zhao Z, Ji L.   +7 more
europepmc   +1 more source

Molecular Fragmentation as a Strategy to Access Hyperpolarised Compounds from Para‐Hydrogen

ChemPhysChem, Accepted Article.
Hyperpolarisation significantly increases the detectability of molecules in magnetic resonance spectroscopy and imaging. Beyond recent advancements in hardware and catalyst design, this article discusses harnessing the inherent chemical reactivity of hyperpolarisation target molecules as a strategy to expand the scope and versatility of para‐hydrogen ...
Philip L. Norcott
wiley   +1 more source

Novel Expression of Apical Bile Acid Transport (ASBT) More Proximally Than Distal Ileum Contributing to Enhanced Intestinal Bile Acid Absorption in Obesity. [PDF]

Int J Mol Sci
Sundaram S, Jagadeesan A, Paulraj RS, Sundaram U, Arthur S.   +4 more
europepmc   +1 more source