Results 291 to 300 of about 63,714 (388)

Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications

Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.
The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff, Jemma Arakelyan, Billy Wai‐Lung Ng   +2 more
wiley   +1 more source

Potent Probiotic Yeast <i>Saccharomyces cerevisiae</i> TBRC 3616: Production Development for Food and Feed Applications. [PDF]

ACS Omega
Antimanon S, Rattanaphan N, Nopgason R, Dechpreechakul T, Chamkhuy W, Kingcha Y, Jindamorakot S, Am-In S, Veeranondha S, Chokpipatpol K, Laoteng K.   +10 more
europepmc   +1 more source

In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug‐Metabolizing Enzymes

The Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.
Abstract Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan‐genotypic inhibitory activity against hepatitis C virus. In vitro studies assessing the inhibition or induction potential of bemnifosbuvir on the CYP450 and UGT1A1 enzymes demonstrated that bemnifosbuvir is a weak inducer and a reversible and time‐dependent inhibitor of
Xiao‐Jian Zhou, Alex Vo, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Keith Pietropaolo, Bruce Belanger, Steven Good, Arantxa Horga, Nancy Agrawal, Janet Hammond   +10 more
wiley   +1 more source

Gut Microbiome Dysbiosis Promotes Gallstone Formation via Bile Acid Metabolic Disorder: A Multiomics Study. [PDF]

FASEB J
Huang C, Xiao W, Zhao J, Zhong R, Gao L, Ma H, Tian L, Yue P, Lin Y, He Q, Xia B, Yuan J, Yang M, Meng W.   +13 more
europepmc   +1 more source

Effect of pork carnosine level on lipid and protein oxidation markers during in vitro co‐digestion in a Mediterranean meal model

Journal of the Science of Food and Agriculture, Volume 106, Issue 7, Page 4008-4016, May 2026.
Abstract BACKGROUND This study assessed the effects of dietary carnosine during the in vitro digestion of a healthy meal model based on the Mediterranean diet, comprising lean pork enriched with two levels of carnosine, whole grain bread, tomato, onion, and olive oil.
Yi Yao Li, Varoujan Yaylayan, Marie‐France Palin, Tania M. Ngapo, Simon Cliche, Fleur Gagnon, Claude Gariépy   +6 more
wiley   +1 more source

The Type VI secretion system in enteric pathogen colonization: molecular mechanisms, ecological dynamics, and therapeutic potential. [PDF]

Front Microbiol
Sui C, Qiao H.
europepmc   +1 more source

A Biomimetic Micro‐Nano System Maximizing ‘Active Transport and Retention’ Effect in Solid Tumors

Small, Volume 22, Issue 25, 4 May 2026.
The Active Transport and Retention (ATR) strategy is realized using a biomimetic micro‐nano system (PG@BAM‐LRC), achieving superior tumor accumulation and efficacy in low‐EPR pancreatic tumors. Platelet (PG)‐derived microcarriers enable tumor‐homing and MMP‐9‐responsive release of nanoliposomes (LRC), while berbamine (BAM) promotes transendothelial ...
Kaiyun Yang, Jiajia Su, Alan J. Davidson, Zimei Wu, Wenli Zhang   +4 more
wiley   +1 more source

Lipidome remodeling in primary biliary cholangitis. [PDF]

Lipids Health Dis
Rogalska M, Rogalski P, Andrzejuk A, Błachnio-Zabielska A, Zabielski P, Flisiak R.   +5 more
europepmc   +1 more source

Optimizing Cassava Starch Residue Inclusion in Broiler Diets: Balancing Growth Performance, Liver Health and Gut Microbial Dynamics

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
Moderate inclusion (20–30%) of cassava starch residue in broiler diets improved gut morphology and reduced E. coli counts with minimal adverse effects, while higher levels impaired growth and liver health. The findings highlight CSR's potential as a partial maize replacement, but caution is needed at elevated inclusion rates.
Agnes Osei‐Adjei, Jacob Alhassan Hamidu, Benjamin Adjei‐Mensah, Yolanda Ashie, Leonardo Abormegah, Florence Martey, Ignitious Nyarko Sarpong, Goodman Sarfo Kantanka, Armstrong Donkoh   +8 more
wiley   +1 more source

Hepatic protein kinase Cβ antagonizing p38^MAPK to activate ERK1/2 to dysregulate biliary lipid composition upon lithogenic stress. [PDF]

Am J Physiol Gastrointest Liver Physiol
Shu Y, Rai A, Sizemore GM, Ostrowski M, Huang W, Mehta KD.   +5 more
europepmc   +1 more source