Results 51 to 60 of about 286,506 (354)

Impairment of the Organization of Locomotor and Exploratory Behaviors in Bile Duct-Ligated Rats

PLoS ONE, 2012
Hepatic encephalopathy (HE) arises from acute or chronic liver diseases and leads to several problems, including motor impairment. Animal models of chronic liver disease have extensively investigated the mechanisms of this disease.
R. Leke, Diogo L. de Oliveira, B. H. Mussulini, M. S. Pereira, Vanessa Kazlauckas, Guilherme S. Mazzini, C. R. Hartmann, T. R. Silveira, Mette Simonsen, L. K. Bak, H. Waagepetersen, S. Keiding, A. Schousboe, L. Portela   +13 more
semanticscholar   +1 more source

Vasopressin regulates the growth of the biliary epithelium in polycystic liver disease [PDF]

, 2016
The neurohypophysial hormone arginine vasopressin (AVP) acts by three distinct receptor subtypes: V1a, V1b, and V2. In the liver, AVP is involved in ureogenesis, glycogenolysis, neoglucogenesis and regeneration. No data exist about the presence of AVP in
Alpini, Gianfranco, Carpino, Guido, Franchitto, Antonio, Gaudio, Eugenio, Glaser, Shannon, Mancinelli, Romina, Olivero, Francesca, Onori, Paolo, Pannarale, Luigi, Sferra, Roberta, Venter, Julie, Vetuschi, Antonella   +11 more
core   +1 more source

Bioengineered 3D hPSC‐Cholangiocyte Ducts With Physiological Signals for Biliary Disease Modeling

Advanced Healthcare Materials, EarlyView.
Tian and colleagues generated a bioengineered bile duct from human pluripotent stem cell (hPSC)‐derived intrahepatic cholangiocytes within a high‐throughput, 384‐well platform to systematically examine the influence of biliary physiological signals including fluid flow, stromal cells and bile acids, and models intrahepatic biliary disease progression ...
Britney Tian, Mina Ogawa, Manami Kondo, Gabrielle Langeveld, Ling Jun Huan, Feng Zhang, Andrew Hollinger, Sara Deir, Christine Bear, Boyang Zhang, Shinichiro Ogawa   +10 more
wiley   +1 more source

Recent research progresses of bioengineered biliary stents

Materials Today Bio
Bile duct lesion, including benign (eg. occlusion, cholelithiasis, dilatation, malformation) and malignant (cholangiocarcinoma) diseases, is a frequently encountered challenge in hepatobiliary diseases, which can be repaired by interventional or surgical
Jianing Yan, Zhichao Ye, Xiaofeng Wang, Danyang Zhong, Ziyuan Wang, Tingting Yan, Tianyu Li, Yuyang Yuan, Yu Liu, Yifan Wang, Xiujun Cai   +10 more
doaj   +1 more source

Fasciola Hepatica Case with Hemobilia

Acta Medica, 2007
Fasciola hepatica (FH) can lead to important hepatobiliary diseases. Here we present a case of hemobilia associated with biliary FH, which is quite a rare case.
Ibrahim Halil Bahcecioglu, Hüseyin Ataseven, Erhan Aygen, Serdar Coskun, Nalan Kuzu, Fulya Ilhan   +5 more
doaj   +1 more source

Benign disease of the common bile duct

Journal of British Surgery, 1988
Abstract The incidence of common bile duct (CBD) pathology in a group of patients with benign biliary disease (n = 505) was found to be 23.2 per cent. The spectrum included 111 patients (90.2 per cent) with CBD stones, 37 of whom (33.3 per cent) had no symptoms or findings pre-operatively indicating CBD involvement.
R, Saxena, R, Pradeep, J, Chander, P, Kumar, J D, Wig, R V, Yadav, S P, Kaushik   +6 more
openaire   +2 more sources

Human hepatic organoids for the analysis of human genetic diseases.

JCI Insight, 2017
We developed an in vitro model system where induced pluripotent stem cells (iPSCs) differentiate into 3-dimensional human hepatic organoids (HOs) through stages that resemble human liver during its embryonic development.
Y. Guan, Dan-ling Xu, Phillip M. Garfin, U. Ehmer, Melissa Hurwitz, G. Enns, S. Michie, Manhong Wu, Ming Zheng, T. Nishimura, J. Sage, G. Peltz   +11 more
semanticscholar   +1 more source

Enhanced Endoscopic Internal Drainage of Gastric Abscess Through Additively Manufactured Stents

Advanced Healthcare Materials, EarlyView.
Postoperative gastric leaks are often treated with off‐label biliary double‐pigtail stents, yet conventional extruded designs are not optimized for leak anatomy, can migrate, and may limit abscess evacuation. PETALS is introduced to optimize transmural drainage geometry and enable patient‐specific 3D‐printable stents.
Parima Phowarasoontorn, Yongbin Ko, Juan S. Barajas‐Gamboa, Juan P. Pantoja, Oraib Al‐Ketan, Mohamed Ali, Sungyun Sohn, Heba Tageldeen Naser, Abdel‐Hameed Dabbour, Batoul Khlaifat, Ahmed AlZubaidi, Carlos Abril Vega, John Rodriguez, Matthew Kroh, Khalil B. Ramadi   +14 more
wiley   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases [PDF]

, 2020
In the past ten years, our understanding of the importance of bile acids has expanded from fat absorption and glucose/lipid/energy homeostasis into potential therapeutic targets for amelioration of chronic cholestatic liver diseases.
Alpini, Gianfranco, Francis, Heather, Kennedy, Lindsey, Kundu, Debjyoti, Meadows, Vik   +4 more
core   +1 more source